YMC SFC Columns
YMC columns for SFC
YMC offers chiral and achiral phases for supercritical fluid chromatography (SFC) applications to provide the chemist with a number of options for SFC separations.
SFC can offer some advantages over HPLC for similar applications. The low viscosity of supercritical carbon dioxide allows for analytical separations 3-5 times faster than those for normal phase HPLC. Speed of the SFC separations, conservation of organic solvents, and more concentrated product fractions make SFC a desirable preparative chromatographic technique for purifying chemical mixtures.
YMC's Alcyon SFC columns are specifically packed in a SFC compatible hardware and are tested under SFC conditions. Further, most of the standard LC columns can be used in SFC mode as well.
YMC SFC columns are characterised by:
- 11 chiral/achiral phases (+ 4 additional phases)
- conventional LC hardware 100% compatible with SFC (statement available)
- hardware especially dedicated to SFC use available (Alcyon SFC)
- analytical or preparative scale application
- YMC's hallmark attention to particle and chemistry specifications and quality
- column certificate in SFC mode (for Alcyon SFC columns)
Available Alcyon phases are (also available in standard LC columns):
| Application | Columns | Compound name | |
| Acidic non-steroidal anti-inflammatory drugs | Alcyon SFC SIL | Ibuprofen Fenoprofen Naproxen Ketoprofen Sulindac | |
| Analgesics | Alcyon SFC SIL | Apronalide Bromovalerylurea Ibuprofen Caffeine Acetylsalicylic acid Acetaminophen Indomethacin | |
| Androgens | Alcyon SFC Triart PFP | Androsterone Dehydroisoandrosterone Testosterone Fluoxymesterone | |
| Antiepileptics | Alcyon SFC SIL | Phenytoin Carbamazepine Primidone | |
| Betablocker | Alcyon SFC Triart Diol | Timolol Metoprolol Propranolol Acebutolol Pindolol Atenolol Carvedilol | |
| Donepezil | Alcyon SFC CSP Cellulose-C | Donepezil | |
| Ingredients in a cough/cold medication | Alcyon SFC Triart PFP | Ibuprofen Acetaminophen Caffeine Dextromethorphan | |
| N-CBZ-DL-Alanine | Alcyon SFC CSP Amylose-C | N-CBZ-DL-Alanine | |
| Naringenin | Alcyon SFC CSP Cellulose-SB | Naringenin | |
| Polyaromatic hydrocarbons | Alcyon SFC Triart C18 | Naphthalene Biphenyl Acenaphthene o-Terphenyl Anthracene m-Terphenyl p-Terphenyl Triphenylene | |
| Propranolol | Alcyon SFC CSP Cellulose-C | Propranolol | |
| Purine alkaloids | Alcyon SFC Triart Diol | Trigonelline hydrochloride Phenol Caffeine Theophylline Theobromine | |
| Steroids | Alcyon SFC Triart Diol | Progesterone Corticosterone Deoxycorticosterone Hydrocortisone |
Specifications Alcyon Chiral/Achiral
|
Alcyon SFC CSP
Amylose-SA
|
Alcyon SFC CSP
Cellulose-SB
|
Alcyon SFC CSP
Cellulose-SC
|
Alcyon SFC CSP
Cellulose-SJ
|
|||
| Chiral Selector |
Amylose
|
Cellulose
|
Cellulose
|
Cellulose | ||
|
tris (3,5-dimethylphenyl-
carbamate)
|
tris (3,5-dimethylphenyl-
carbamate)
|
tris (3,5-dichlorophenyl-
carbamate)
|
tris (4-methylbenzoate)
|
|||
| USP |
L99
|
-
|
- |
-
|
||
| Particle Size [µm] | 3, 5 | |||||
| Type | immobilised | |||||
| pH Range | 2.0 - 9.0 | |||||
| Shipping Solvent | 2-propanol | |||||
| Pressure Limit |
Inner diameter of 2.1 / 3.0 / 4.6 mm: 300 bar
Inner diameter of 10 / 20 mm: 200 bar
|
|||||
| Alcyon SFC CSP Amylose-C | Alcyon SFC CSP Cellulose-C | |
| Chiral Selector | Amylose | Cellulose |
|
tris (3,5-dimethylphenyl-
carbamate)
|
||
| USP |
L51
|
L40 |
| Particle Size [µm] | 3, 5 | |
| Type | coated | |
| pH Range | 3.5 - 6.5 | |
| Shipping Solvent | 2-propanol | |
| Pressure Limit |
Inner diameter of 2.1 / 3.0 / 4.6 mm: 300 bar
Inner diameter of 10 / 20 mm: 200 bar
|
|
|
Alcyon SFC
Triart C18
|
Alcyon SFC
Triart Diol
|
Alcyon SFC
Triart PFP
|
Alcyon SFC
CN
|
Alcyon SFC
SIL
|
|
| Modification | C18 | 1,2-Dihydroxypropyl |
Pentafluorophenylpropyl
|
Cyanopropyl | Silica |
| USP | L1 | L20 | L43 | L10 | L3 |
| Particle Size [µm] | 5 | ||||
| Pore Size [nm / Å] | 12 / 120 | ||||
| pH Range | 1.0 - 12.0 | 2.0 - 10.0 | 1.0 - 8.0 | 2.0 - 7.5 | 2.0 - 7.5 |
| Shipping Solvent | 2-propanol | ||||
| Pressure Limit |
Inner diameter of 2.1 / 4.6 mm: 300 bar
Inner diameter of 10* / 20* mm: 200 bar
|
||||
* only Alcyon SFC CN and Alcyon SFC SIL in 10/20 mm ID available
Specifications Additional Phases
|
YMC-Pack
2-Ethyl pyridine*
|
YMC-Pack
Diethylaminopropyl*
|
YMC-Pack
Propyl acetamide*
|
YMC-Pack
Pyridine amide*
|
|
| Particle Size [µm] | 5 (3 and 10 on request) | |||
| Pore Size [nm / Å] | 6 / 60 | |||
| Shipping Solvent | 2-propanol | |||
| Pressure Limit | 250 bar | |||
*not in Alcyon Hardware, but in so called "PS" type hardware also exclusively dedicated to SFC use
| Title | Document Type | Language | Phase Type | Download |
| Rapid SFC Analysis of Vitamin D3 and Related Compounds with Alcyon SFC Triart-Diol | Application Note | E | ||
| Alcyon SFC Columns | Brochure | E | ||
| Alcyon SFC Amloyse-SA, Cellulose-SB, Cellulose-SC Care and Use | Care and Use Instructions | E | ||
| Alcyon SFC Amylose-C, Amylose-C Neo, Cellulose-C Care and Use | Care and Use Instructions | E | ||
| Alcyon SFC Cellulose-SJ (immobilised) Care and Use | Care and Use Instructions | E | ||
| Alcyon SFC Triart Diol, C18, PFP, SIL, CN Care and Use | Care and Use Instructions | E | ||
| Fast Method Screening for Separation of Enantiomers in HPLC and SFC Utilizing Novel Polysaccharide Type Chiral Stationary Phase | Poster | E | Please login | |
| SFC Analytical Method Development for Vitamin D3 and Related Compounds | Poster | E | Please login | |
| Toward Development of “Generic” Separation Methods for Achiral Pharmaceutical Analysis Using SFC | Poster | E | Please login | |
| Analyse von biologisch aktiven Verbindungen mit CHIRAL ART Amylose-SA im SFC-Modus | Product Information | D | Please login | |
| Analysis of biologically active compounds using CHIRAL ART Amylose-SA in SFC mode | Product Information | E | Please login |
Please login to see the prices (if needed insert link to login page).
| Product | Description | Price (EUR) | Stock |
| CN12S05-1546WTS | Alcyon SFC CN, Classical Analytical SFC Column (4.6 mm i.d.), 12 nm, S-5 µm, 150 x 4.6 mm | - | |
| CN12S05-15Q1WTS | Alcyon SFC CN, Narrowbore SFC Column (2.1 mm i.d.), 12 nm, S-5 µm, 150 x 2.1 mm | - | |
| CN12S05-2510WTS | Alcyon SFC CN, semi-preparative SFC column (10 mm i.d.), 12 nm, S-5 µm, 250 x 10.0 mm | - | |
| CN12S05-2520WTS | Alcyon SFC CN, semi-preparative SFC column (20 mm i.d.), 12 nm, S-5 µm, 250 x 20.0 mm | - | |
| CN12S05-2546WTS | Alcyon SFC CN, Classical Analytical SFC Column (4.6 mm i.d.), 12 nm, S-5 µm, 250 x 4.6 mm | - | |
| KAN99S03-0503WTS | Alcyon SFC CSP Amylose-C, Classical Analytical SFC Column (3.0 mm i.d.), S-3 µm, 50 x 3.0 mm | - | |
| KAN99S03-1003WTS | Alcyon SFC CSP Amylose-C, Classical Analytical SFC Column (3.0 mm i.d.), S-3 µm, 100 x 3.0 mm | - | |
| KAN99S03-1503WTS | Alcyon SFC CSP Amylose-C, Classical Analytical SFC Column (3.0 mm i.d.), S-3 µm, 150 x 3.0 mm | - | |
| KAN99S03-1546WTS | Alcyon SFC CSP Amylose-C, Classical Analytical SFC Column (4.6 mm i.d.), S-3 µm, 150 x 4.6 mm | - | |
| KAN99S03-15Q1WTS | Alcyon SFC CSP Amylose-C, Classical Analytical SFC Column (2.1 mm i.d.), S-3 µm, 150 x 2.1 mm | - | |
| KAN99S03-2546WTS | Alcyon SFC CSP Amylose-C, Classical Analytical SFC Column (4.6 mm i.d.), S-3 µm, 250 x 4.6 mm | - | |
| KAN99S05-1546WTS | Alcyon SFC CSP Amylose-C, Classical Analytical SFC Column (4.6 mm i.d.), S-5 µm, 150 x 4.6 mm | - | |
| KAN99S05-15Q1WTS | Alcyon SFC CSP Amylose-C, Narrowbore SFC Column (2.1 mm i.d.), S-5 µm, 150 x 2.1 mm | - | |
| KAN99S05-2510WTS | Alcyon SFC CSP Amylose-C, semi-preparative SFC column (10.0 mm i.d.), S-5 µm, 250 x 10.0 mm | - | |
| KAN99S05-2520WTS | Alcyon SFC CSP Amylose-C, semi-preparative SFC column (20.0 mm i.d.), S-5 µm, 250 x 20.0 mm | - | |
| KAN99S05-2546WTS | Alcyon SFC CSP Amylose-C, Classical Analytical SFC Column (4.6 mm i.d.), S-5 µm, 250 x 4.6 mm | - | |
| KCN99S03-0503WTS | Alcyon SFC CSP Cellulose-C, Classical Analytical SFC Column (3.0 mm i.d.), S-3 µm, 50 x 3.0 mm | - | |
| KCN99S03-1003WTS | Alcyon SFC CSP Cellulose-C, Classical Analytical SFC Column (3.0 mm i.d.), S-3 µm, 100 x 3.0 mm | - | |
| KCN99S03-1503WTS | Alcyon SFC CSP Cellulose-C, Classical Analytical SFC Column (3.0 mm i.d.), S-3 µm, 150 x 3.0 mm | - | |
| KCN99S03-1546WTS | Alcyon SFC CSP Cellulose-C, Classical Analytical SFC Column (4.6 mm i.d.), S-3 µm, 150 x 4.6 mm | - | |
| KCN99S03-15Q1WTS | Alcyon SFC CSP Cellulose-C, Classical Analytical SFC Column (2.1 mm i.d.), S-3 µm, 150 x 2.1 mm | - | |
| KCN99S03-2546WTS | Alcyon SFC CSP Cellulose-C, Classical Analytical SFC Column (4.6 mm i.d.), S-3 µm, 250 x 4.6 mm | - | |
| KCN99S05-1546WTS | Alcyon SFC CSP Cellulose-C, Classical Analytical SFC Column (4.6 mm i.d.), S-5 µm, 150 x 4.6 mm | - | |
| KCN99S05-15Q1WTS | Alcyon SFC CSP Cellulose-C, Narrowbore SFC Column (2.1 mm i.d.), S-5 µm, 150 x 2.1 mm | - | |
| KCN99S05-2510WTS | Alcyon SFC CSP Cellulose-C, semi-preparative SFC column (10.0 mm i.d.), S-5 µm, 250 x 10.0 mm | - | |
| KCN99S05-2520WTS | Alcyon SFC CSP Cellulose-C, semi-preparative SFC column (20.0 mm i.d.), S-5 µm, 250 x 20.0 mm | - | |
| KCN99S05-2546WTS | Alcyon SFC CSP Cellulose-C, Classical Analytical SFC Column (4.6 mm i.d.), S-5 µm, 250 x 4.6 mm | - | |
| KSA99S03-0503WTS | Alcyon SFC CSP Amylose-SA, Classical Analytical SFC Column (3.0 mm i.d.), S-3 µm, 50 x 3.0 mm | - | |
| KSA99S03-1003WTS | Alcyon SFC CSP Amylose-SA, Classical Analytical SFC Column (3.0 mm i.d.), S-3 µm, 100 x 3.0 mm | - | |
| KSA99S03-1503WTS | Alcyon SFC CSP Amylose-SA, Classical Analytical SFC Column (3.0 mm i.d.), S-3 µm, 150 x 3.0 mm | - | |
| KSA99S03-1546WTS | Alcyon SFC CSP Amylose-SA, Classical Analytical SFC Column (4.6 mm i.d.), S-3 µm, 150 x 4.6 mm | - | |
| KSA99S03-15Q1WTS | Alcyon SFC CSP Amylose-SA, Classical Analytical SFC Column (2.1 mm i.d.), S-3 µm, 150 x 2.1 mm | - | |
| KSA99S03-2546WTS | Alcyon SFC CSP Amylose-SA, Classical Analytical SFC Column (4.6 mm i.d.), S-3 µm, 250 x 4.6 mm | - | |
| KSA99S05-1546WTS | Alcyon SFC CSP Amylose-SA, Classical Analytical SFC Column (4.6 mm i.d.), S-5 µm, 150 x 4.6 mm | - | |
| KSA99S05-15Q1WTS | Alcyon SFC CSP Amylose-SA, Narrowbore SFC Column (2.1 mm i.d.), S-5 µm, 150 x 2.1 mm | - | |
| KSA99S05-2510WTS | Alcyon SFC CSP Amylose-SA, semi-preparative SFC column (10.0 mm i.d.), S-5 µm, 250 x 10.0 mm | - | |
| KSA99S05-2520WTS | Alcyon SFC CSP Amylose-SA, semi-preparative SFC column (20.0 mm i.d.), S-5 µm, 250 x 20.0 mm | - | |
| KSA99S05-2546WTS | Alcyon SFC CSP Amylose-SA, Classical Analytical SFC Column (4.6 mm i.d.), S-5 µm, 250 x 4.6 mm | - | |
| KSB99S03-0503WTS | Alcyon SFC CSP Cellulose-SB, Classical Analytical SFC Column (3.0 mm i.d.), S-3 µm, 50 x 3.0 mm | - | |
| KSB99S03-1003WTS | Alcyon SFC CSP Cellulose-SB, Classical Analytical SFC Column (3.0 mm i.d.), S-3 µm, 100 x 3.0 mm | - | |
| KSB99S03-1503WTS | Alcyon SFC CSP Cellulose-SB, Classical Analytical SFC Column (3.0 mm i.d.), S-3 µm, 150 x 3.0 mm | - | |
| KSB99S03-1546WTS | Alcyon SFC CSP Cellulose-SB, Classical Analytical SFC Column (4.6 mm i.d.), S-3 µm, 150 x 4.6 mm | - | |
| KSB99S03-15Q1WTS | Alcyon SFC CSP Cellulose-SB, Classical Analytical SFC Column (2.1 mm i.d.), S-3 µm, 150 x 2.1 mm | - | |
| KSB99S03-2546WTS | Alcyon SFC CSP Cellulose-SB, Classical Analytical SFC Column (4.6 mm i.d.), S-3 µm, 250 x 4.6 mm | - | |
| KSB99S05-1546WTS | Alcyon SFC CSP Cellulose-SB, Classical Analytical SFC Column (4.6 mm i.d.), S-5 µm, 150 x 4.6 mm | - | |
| KSB99S05-15Q1WTS | Alcyon SFC CSP Cellulose-SB, Narrowbore SFC Column (2.1 mm i.d.), S-5 µm, 150 x 2.1 mm | - | |
| KSB99S05-2510WTS | Alcyon SFC CSP Cellulose-SB, semi-preparative SFC column (10.0 mm i.d.), S-5 µm, 250 x 10.0 mm | - | |
| KSB99S05-2520WTS | Alcyon SFC CSP Cellulose-SB, semi-preparative SFC column (20.0 mm i.d.), S-5 µm, 250 x 20.0 mm | - | |
| KSB99S05-2546WTS | Alcyon SFC CSP Cellulose-SB, Classical Analytical SFC Column (4.6 mm i.d.), S-5 µm, 250 x 4.6 mm | - | |
| KSC99S03-0503WTS | Alcyon SFC CSP Cellulose-SC, Classical Analytical SFC Column (3.0 mm i.d.), S-3 µm, 50 x 3.0 mm | - | |
| KSC99S03-1003WTS | Alcyon SFC CSP Cellulose-SC, Classical Analytical SFC Column (3.0 mm i.d.), S-3 µm, 100 x 3.0 mm | - | |
| KSC99S03-1503WTS | Alcyon SFC CSP Cellulose-SC, Classical Analytical SFC Column (3.0 mm i.d.), S-3 µm, 150 x 3.0 mm | - | |
| KSC99S03-1546WTS | Alcyon SFC CSP Cellulose-SC, Classical Analytical SFC Column (4.6 mm i.d.), S-3 µm, 150 x 4.6 mm | - | |
| KSC99S03-15Q1WTS | Alcyon SFC CSP Cellulose-SC, Classical Analytical SFC Column (2.1 mm i.d.), S-3 µm, 150 x 2.1 mm | - | |
| KSC99S03-2546WTS | Alcyon SFC CSP Cellulose-SC, Classical Analytical SFC Column (4.6 mm i.d.), S-3 µm, 250 x 4.6 mm | - | |
| KSC99S05-1546WTS | Alcyon SFC CSP Cellulose-SC, Classical Analytical SFC Column (4.6 mm i.d.), S-5 µm, 150 x 4.6 mm | - | |
| KSC99S05-15Q1WTS | Alcyon SFC CSP Cellulose-SC, Narrowbore SFC Column (2.1 mm i.d.), S-5 µm, 150 x 2.1 mm | - | |
| KSC99S05-2510WTS | Alcyon SFC CSP Cellulose-SC, semi-preparative SFC column (10.0 mm i.d.), S-5 µm, 250 x 10.0 mm | - | |
| KSC99S05-2520WTS | Alcyon SFC CSP Cellulose-SC, semi-preparative SFC column (20.0 mm i.d.), S-5 µm, 250 x 20.0 mm | - | |
| KSC99S05-2546WTS | Alcyon SFC CSP Cellulose-SC, Classical Analytical SFC Column (4.6 mm i.d.), S-5 µm, 250 x 4.6 mm | - | |
| KSJ99S03-0503WTS | Alcyon SFC CSP Cellulose-SJ, Classical Analytical SFC Column (3.0 mm i.d.), S-3 µm, 50 x 3.0 mm | - | |
| KSJ99S03-1003WTS | Alcyon SFC CSP Cellulose-SJ, Classical Analytical SFC Column (3.0 mm i.d.), S-3 µm, 100 x 3.0 mm | - | |
| KSJ99S03-1503WTS | Alcyon SFC CSP Cellulose-SJ, Classical Analytical SFC Column (3.0 mm i.d.), S-3 µm, 150 x 3.0 mm | - | |
| KSJ99S03-1546WTS | Alcyon SFC CSP Cellulose-SJ, Classical Analytical SFC Column (4.6 mm i.d.), S-3 µm, 150 x 4.6 mm | - | |
| KSJ99S03-15Q1WTS | Alcyon SFC CSP Cellulose-SJ, Classical Analytical SFC Column (2.1 mm i.d.), S-3 µm, 150 x 2.1 mm | - | |
| KSJ99S03-2546WTS | Alcyon SFC CSP Cellulose-SJ, Classical Analytical SFC Column (4.6 mm i.d.), S-3 µm, 250 x 4.6 mm | - | |
| SL12S05-1546WTS | Alcyon SFC SIL (Silica), Classical Analytical SFC Column (4.6 mm i.d.), 12 nm, S-5 µm, 150 x 4.6 mm | - | |
| SL12S05-15Q1WTS | Alcyon SFC SIL (Silica), Narrowbore SFC Column (2.1 mm i.d.), 12 nm, S-5 µm, 150 x 2.1 mm | - | |
| SL12S05-2510WTS | Alcyon SFC SIL (Silica), semi-preparative SFC column (10 mm i.d.), 12 nm, S-5 µm, 250 x 10.0 mm | - | |
| SL12S05-2520WTS | Alcyon SFC SIL (Silica), semi-preparative SFC column (20 mm i.d.), 12 nm, S-5 µm, 250 x 20.0 mm | - | |
| SL12S05-2546WTS | Alcyon SFC SIL (Silica), Classical Analytical SFC Column (4.6 mm i.d.), 12 nm, S-5 µm, 250 x 4.6 mm | - | |
| TA12S05-1546WTS | Alcyon SFC Triart C18, Classical Analytical SFC Column (4.6 mm i.d.), 12 nm, S-5 µm, 150 x 4.6 mm | - | |
| TA12S05-15Q1WTS | Alcyon SFC Triart C18, Narrowbore SFC Column (2.1 mm i.d.), 12 nm, S-5 µm, 150 x 2.1 mm | - | |
| TA12S05-2546WTS | Alcyon SFC Triart C18, Classical Analytical SFC Column (4.6 mm i.d.), 12 nm, S-5 µm, 250 x 4.6 mm | - | |
| TDN12S03-2546WTS | Alcyon SFC Triart Diol, Classical Analytical SFC Column (4.6 mm i.d.), 12 nm, S-3 µm, 250 x 4.6 mm | - | |
| TDN12S05-1546WTS | Alcyon SFC Triart Diol, Classical Analytical SFC Column (4.6 mm i.d.), 12 nm, S-5 µm, 150 x 4.6 mm | - | |
| TDN12S05-15Q1WTS | Alcyon SFC Triart Diol, Narrowbore SFC Column (2.1 mm i.d.), 12 nm, S-5 µm, 150 x 2.1 mm | - | |
| TDN12S05-2546WTS | Alcyon SFC Triart Diol, Classical Analytical SFC Column (4.6 mm i.d.), 12 nm, S-5 µm, 250 x 4.6 mm | - | |
| TPF12S05-1546WTS | Alcyon SFC Triart PFP, Classical Analytical SFC Column (4.6 mm i.d.), 12 nm, S-5 µm, 150 x 4.6 mm | - | |
| TPF12S05-15Q1WTS | Alcyon SFC Triart PFP, Narrowbore SFC Column (2.1 mm i.d.), 12 nm, S-5 µm, 150 x 2.1 mm | - | |
| TPF12S05-2546WTS | Alcyon SFC Triart PFP, Classical Analytical SFC Column (4.6 mm i.d.), 12 nm, S-5 µm, 250 x 4.6 mm | - |
- 2-3 days
- 1-2 weeks
- 3-4 weeks
