YMC Chiral Bulk
Efficient Chiral Separations
Preparative Scale YMC CHIRAL is suitable both for the conventional column separations and also for dynamic axial compression (DAC) columns and simulated moving bed (SMB) systems.
YMC CHIRAL bulk material is available up to several hundred kilograms with YMC's well known high quality, reproducibility and technical support. It provides a significant tool for downstream processing at pilot production scale.
Combined with the surprising cost-efficiency, YMC CHIRAL is regarded highly for development or upscaling of chiral purification processes. In addition, method development is simplified by scouting columns for selectivity screening.
Available Phases are:
- CHIRAL ART Amylose-C (Neo)
- CHIRAL ART Amylose-SA
- CHIRAL ART Cellulose-C
- CHIRAL ART Cellulose-SB
- CHIRAL ART Cellulose-SC
- CHIRAL ART Cellulose-SJ
|CHIRAL ART Amylose-C (Neo)||CHIRAL ART Cellulose-C|
|Phase Code||KAN (KBN)||KCN|
|Particle Sizes [µm]||10, 20|
|pH Range||3.5 - 6.5|
|Particle Sizes [µm]||10, 20|
|pH Range||2.0 - 9.0|
For the competitor’s product, loading amount of more than 0.1 mg was not possible because the enantiomeric excess of the 2nd peak was already less than 98%ee with a loading amount of 0.1 mg.
|CHIRAL ART Cellulose-SB||CHIRALPAK® IB|
|1st peak||2nd peak||1st peak||2nd peak|
The calculated maximum loading amount on CHIRAL ART Cellulose-SB of 1.6 mg was 10 times
larger than that obtained for the competitor’s product due to the large differences in the peak
shapes, even though the interval between repeat injections was higher!
250 x 4.6 mm ID
250 x 20 mm ID
250 x 50 mm ID
|1st peak||2nd peak||1st peak||2nd peak||1st peak||2nd peak|
Linear scale-up was performed using the appropriate scale-up factors. The Dynamic Axial Compression Column self-packed with CHIRAL ART Cellulose-SB 10 μm can be easily and linearly scaled-up for a greater purification scale. The final productivity is 366 and 390 mg/h respectively for peak 1 and 2.
A selection of chiral applications can be foundat http://ymc.de/applications.html. Here, you can search for chiral applications already known for your compounds.
Test Columns or Screening Kits
You can request a test column to initially test a chiral column before finally buy it if it works for your application. If the column is not suitable, simply return it without any further requirements.
Alternatively you can choose one of the YMC method development kits (see page 13) or requesta customised screening kit with 2, 3, 4 or 5 different CHIRAL ART phases. You only need to contact your local YMC contact for details.
FREE Chiral Screening Service
- >90% success rate
- Rapid screening within a short period of time
- Screening according to your requirements: e.g. RP-mode, MS-compatibility etc.
- Screening on all available CHIRAL ART phases and further YMC CHIRAL phases if needed
- Results presented in a detailed report
- Confidentiality Agreements can be arranged as necessary
- Hit criteria : Rs>1.5
- Hit database: compiled from 300 samples (199 LC/101 SFC) supplied for contract service
- The 5 CHIRAL ART phases available so far can cover >90% of chiral separations
- Hit ratios varied between 6% and 34% for each of the 5 phases
- About 95% of the LC applications are in NP/PO mode, while 5% are in RP mode
- Method development based on phase screening
- According to your requirements
Preparative and Process Scale-Up
- Phase screening
- Preparative method development
- Small scale purification
|Title||Document Type||Language||Phase Type||Download|
|Robust and Efficient Purification of Enantiomers with CHIRAL ART Cellulose-SB||Application Note||E|
|YMC Chiral Columns||Brochure||E|
|CHIRAL ART Amylose-C, Cellulose-C Prep Care and Use||Care and Use Instructions||E|
|CHIRAL ART Amylose-SA, Cellulose-SB, Cellulose-SC, Cellulose-SJ Prep Care and Use||Care and Use Instructions||E|
|YMC CHIRAL CD, NEA, Prep Care and Use||Care and Use Instructions||E|
|MSDS Silica based NP/RP Bulk||MSDS||E|
|YMC Bulk Packing Materials for RP-, NP- and Chiral Prep. LC||Overview||E|
|CHIRAL ART Cellulose-SC available in Prep||Product Information||E||Please login|
|Robust and efficient chiral purification||Product Information||E|
Please contact YMC for pricing or specific solutions for your purification process.
Product Manager Bulk Media
ph. +49 (0)2064 427-280
|Particle Size||CHIRAL ART Amylose-C||CHIRAL ART Amylose-SA||CHIRAL ART Cellulose-C||CHIRAL ART Cellulose-SB||CHIRAL ART Cellulose-SC||CHIRAL ART Cellulose-SJ|