Linear scale-up was performed using the appropriate scale-up factors. The Dynamic Axial Compression Column self-packed with CHIRAL ART Cellulose-SB 10 μm can be easily and linearly scaled-up for a greater purification scale. The final productivity is 366 and 390 mg/h respectively for peak 1 and 2.

YMC Database
A selection of chiral applications can be foundat http://ymc.de/applications.html. Here, you can search for chiral applications already known for your compounds.

Test Columns or Screening Kits
You can request a test column to initially test a chiral column before finally buy it if it works for your application. If the column is not suitable, simply return it without any further requirements.
Alternatively you can choose one of the YMC method development kits (see page 13) or requesta customised screening kit with 2, 3, 4 or 5 different CHIRAL ART phases. You only need to contact your local YMC contact for details.

FREE Chiral Screening Service

• >90% success rate
• Rapid screening within a short period of time
• Screening according to your requirements: e.g. RP-mode, MS-compatibility etc.
• Screening on all available CHIRAL ART phases and further YMC CHIRAL phases if needed
• Results presented in a detailed report
• Confidentiality Agreements can be arranged as necessary

Success Rate

• Hit criteria : Rs>1.5
• Hit database: compiled from 300 samples (199 LC/101 SFC) supplied for contract service
• The 5 CHIRAL ART phases available so far can cover >90% of chiral separations
• Hit ratios varied between 6% and 34% for each of the 5 phases
• About 95% of the LC applications are in NP/PO mode, while 5% are in RP mode

Method Development

• Method development based on phase screening
• According to your requirements

Preparative and Process Scale-Up

• Phase screening
• Preparative method development
• Small scale purification