YMC Chiral Bulk

YMC Chiral Bulk

20 μm and 10 μm materials in bulk - in multikilogram amounts

YMC Chiral Bulk

    Efficient Chiral Separations

    Preparative Scale YMC CHIRAL is suitable both for the conventional column separations and also for dynamic axial compression (DAC) columns and simulated moving bed (SMB) systems.

    YMC CHIRAL bulk material is available up to several hundred kilograms with YMC's well known high quality, reproducibility and technical support. It provides a significant tool for downstream processing at pilot production scale.

    Combined with the surprising cost-efficiency, YMC CHIRAL is regarded highly for development or upscaling of chiral purification processes. In addition, method development is simplified by scouting columns for selectivity screening.

    Available Phases are:

    • CHIRAL ART Amylose-C (Neo)
    • CHIRAL ART Amylose-SA
    • CHIRAL ART Cellulose-C
    • CHIRAL ART Cellulose-SB
    • CHIRAL ART Cellulose-SC
      CHIRAL ART Amylose-C (Neo) CHIRAL ART Cellulose-C
    Chiral Selector Amylose Cellulose
    tris (3,5-dimethylphenyl-
    Type coated
    Phase Code KAN (KBN) KCN
    Particle Sizes [µm] 10, 20
    Pore Size widepore
    Separation Mode NP/SFC/SMB
    pH Range 3.5 - 6.5



      CHIRAL ART Amylose-SA CHIRAL ART Cellulose-SB
    Chiral Selector Amylose Cellulose Cellulose
    tris (3,5-dimethylphenyl-
    tris (3,5-dichlorophenyl-
    Type immobilised immobilised
    Phase Code KSA KSB KSC
    Particle Sizes [µm] 10, 20 10, 20
    Pore Size widepore widepore
    Separation Mode RP/NP/SFC/SMB RP/NP/SFC/SMB
    pH Range 2.0 - 9.0 2.0 - 9.0


    YMC  CHIRAL Prep CD available on request.






    For the competitor’s product, loading amount of more than 0.1 mg was not possible because the enantiomeric excess of the 2nd peak was already less than 98%ee with a loading amount of 0.1 mg.


      1st peak 2nd peak 1st peak 2nd peak
    Enantiomeric excess >99.9%ee 99.3%ee >99.9%ee 97.9%ee
    Recovery 99% 99% 99% 97%
    Productivity (mg/h) 3.1 3.3 0.3 0.3


    The calculated maximum loading amount on CHIRAL ART Cellulose-SB of 1.6 mg was 10 times
    larger than that obtained for the competitor’s product due to the large differences in the peak
    shapes, even though the interval between repeat injections was higher!


    Scale-up with YMC-Actus CHIRAL ART


    250 x 4.6 mm ID

    250 x 20 mm ID
    DAC Preparative
    250 x 50 mm ID
      1st peak 2nd peak 1st peak 2nd peak 1st peak 2nd peak
    Enantiomeric excess >99.9%ee >99.3%ee >99.9%ee >99.8%ee >99.1%ee >99.3%ee
    Recovery 99% 99% 97% 99% 99% 94%
    Productivity (mg/h) 3.1 3.3 58.6 62.4 366 390



    Linear scale-up was performed using the appropriate scale-up factors. The Dynamic Axial Compression Column self-packed with CHIRAL ART Cellulose-SB 10 μm can be easily and linearly scaled-up for a greater purification scale. The final productivity is 366 and 390 mg/h respectively for peak 1 and 2.



    How to Choose the Correct Chiral Column

    YMC Database
    A selection of chiral applications can be foundat http://ymc.de/applications.html. Here, you can search for chiral applications already known for your compounds.

    Test Columns or Screening Kits
    You can request a test column to initially test a chiral column before finally buy it if it works for your application. If the column is not suitable, simply return it without any further requirements.
    Alternatively you can choose one of the YMC method development kits (see page 13) or requesta customised screening kit with 2, 3, 4 or 5 different CHIRAL ART phases. You only need to contact your local YMC contact for details.

    FREE Chiral Screening Service

    • >90% success rate
    • Rapid screening within a short period of time
    • Screening according to your requirements: e.g. RP-mode, MS-compatibility etc.
    • Screening on all available CHIRAL ART phases and further YMC CHIRAL phases if needed
    • Results presented in a detailed report
    • Confidentiality Agreements can be arranged as necessary

    Success Rate

    • Hit criteria : Rs>1.5
    • Hit database: compiled from 300 samples (199 LC/101 SFC) supplied for contract service
    • The 5 CHIRAL ART phases available so far can cover >90% of chiral separations
    • Hit ratios varied between 6% and 34% for each of the 5 phases
    • About 95% of the LC applications are in NP/PO mode, while 5% are in RP mode

    Method Development

    • Method development based on phase screening
    • According to your requirements

    Preparative and Process Scale-Up

    • Phase screening
    • Preparative method development
    • Small scale purification
    Title Document Type Language Phase Type Download
    Robust and Efficient Purification of Enantiomers with CHIRAL ART Cellulose-SB Application Note E
    YMC Chiral Columns Brochure E
    CHIRAL ART Amylose-C, Cellulose-C Prep Care and Use Care and Use Instructions E
    CHIRAL ART Amylose-SA, Cellulose-SB, Cellulose-SC, Cellulose-SJ Prep Care and Use Care and Use Instructions E
    YMC CHIRAL CD, NEA, Prep Care and Use Care and Use Instructions E
    MSDS Silica based NP/RP Bulk MSDS E
    Bulk Packing Materials for Preparative Chromatography Overview E
    CHIRAL ART Cellulose-SC available in Prep Product Information E Please login
    Robust and efficient chiral purification Product Information E
    YMC Alternatives to Existing BioLC Columns Product Information E

    Request Now

    Please contact YMC for pricing or specific solutions for your purification process.

    Michael Ostendorf

    Product Manager Bulk Media

    ph. +49 (0)2064 427-280

    Particle Size CHIRAL ART Amylose-C CHIRAL ART Amylose-SA CHIRAL ART Cellulose-C CHIRAL ART Cellulose-SB CHIRAL ART Cellulose-SC
    CD ST
    CD PM
    10 µm KAN99S11 KSA99S11 KCN99S11 KSB99S11 KSC99S11 ST12S11 PM12S11
    20 µm KAN99S21 KSA99S21 KCN99S21 KSB99S21 KSC99S21 ST12S21 PM12S21
    50 µm - - - -   ST12S50 PM12S50


    Related Categories


    • Michael Ostendorf
    • Product Manager
    • Bulk Media
    • ph. +49 (0)2064 427-280