YMC Reversed Phase Classics

*not all combinations of particle and pore size are available

YMC-Pack ODS-AQ is a “hydrophilic” C18 material with a balanced surface chemistry leading to elution of moderately basic compounds with little or no peak tailing and strong retention of polar sample solutes.
YMC-Pack ODS-AQ is able to resolve compounds with minor differences in polarity from closely related substances. As a result, YMC-Pack ODS-AQ is an excellent tool for separating drugs and corresponding metabolites, pesticides and degradation products, or peptides and protein digests etc.

YMC-Pack ODS-A, YMC’s classic reversed phase column, is renowned worldwide because of its unique performance and reproducibility. The classic “workhorse” phase YMC-Pack ODS-A is a fully endcapped material.
YMC-Pack ODS-A is frequently used for polar to moderately nonpolar substances in pharmaceutical, biochemical and environmental applications as well as for separations in the field of food technology.

YMC-Pack ODS-AM is a high quality analytical C18 material, with a very tight specification. Due to the guaranteed long term reproducibility, YMC-Pack ODS-AM columns are the ideal choice for establishing validated HPLC analysis.
YMC-Pack ODS-AM has appropriate selectivity for polar to moderately nonpolar pharmaceuticals, organic intermediates, biological and natural products found in the chemical and pharmaceutical industry.

YMC-Pack ODS-AL uses not only hydrophobic interaction but also secondary interactions with reactive residual silanol groups on the silica surface to affect separation. This results in a different selectivity from conventional ODS columns. YMC-Pack ODS-AL is the ideal choice for mixed mode separations.
Due to the residual silanol groups YMC-Pack ODS-AL shows relatively greater retention of pyridines for example.

YMC-Pack Polymer C18 is prepared from a hydrophilic methacrylate polymer bonded with a hydrophobic octadecylsilane reagent to make the C18 functionality an integral part of the polymeric structure with residual silanols.

The selectivity and retention of YMC-Pack Polymer C18 is similar to that of standard ODS phases. Since it resists shrinking and swelling, YMC-Pack Polymer C18 can be used with eluents ranging in composition from 100% aqueous to 100% organic component and its wide pH range makes it an alternative choice for high pH separations.

YMCbasic shows a different hydrophobicity and represents a complementing selectivity to C8 and C18 materials.

YMCbasic offers high resolution and excellent peak symmetry for basic compounds without the need of ion pair reagents or amine modifiers. Unlike many base-deactivated phases, YMCbasic is also suitable for separation of acidic compounds, showing slight retention of highly polar acid compounds such as maleate.

YMC-Pack C8 is an alternative phase to C18 with moderate hydrophobicity. YMC-Pack C8 is fully endcapped and has a high coverage of monomeric bonded chemistry.

YMC-Pack C8 is suitable for a wide range of sample types including pharmaceuticals and biologicals with a relatively high hydrophobicity.

YMC-Pack Ph has a unique selectivity due to π-π interactions and provides preferential retention of aromatic compounds. YMC-Pack Ph is fully endcapped and has a high coverage of monomeric bonded chemistry.

YMC-Pack Ph offers an alternative selectivity to C18, C8 or C4 bonded phases for the analysis of peptides and other bio molecules.

YMC-Pack C4 is a low hydrophobicity material with a high coverage of monomeric bonded chemistry.
Due to the availability of YMC-Pack C4 wide pore material, it is ideally suited for separation of biological materials.

YMC-Pack PROTEIN-RP is a reversed-phase column utilizing a silica gel base. It contains a stationary phase, specifically designed for separation of proteins or peptides.

Problems that are associated with conventional reversed-phase columns with short alkyl chain lengths are minimised. Robust column lifetime and excellent recovery of hydrophobic proteins are typically possible on this phase.

YMC-Pack TMS is the stationary phase with the lowest hydrophobicity among reversed phase materials. It shows an intermediate polarity between normal phase silica and other alkyl bonded reversed phases.

YMC-Pack TMS is suitable for fast separations of highly hydrophobic compounds. It is an alternative to C18 phases for the separation of hydrophilic compounds.

YMC-Pack CN which consists of silica gel with cyanopropyl groups. It is the most polar reversed phase column. YMC-Pack CN offers a faster column equilibration than normal phase silica gel.

YMC-Pack CN can be used for normal, reversed phase and HILIC applications.

The YMC Carotenoid stationary phase provides sufficient phase thickness to enhance interaction with long chained molecules. Therefore, geometric and positional isomers of conjugated double bonding systems are recognised and resolved by the YMC Carotenoid phase.

YMC Carotenoid can also be used for various analytes, including polar carotenes, polar and nonpolar xanthophylls, steroids, retinols and fat-soluble vitamins. The phase is an excellent choice for LC-MS applications.

Comparison of the film thickness of C18 and C30 stationary phases with the molecular length of β-carotene (determined with Small Angle Neutron Scattering (SANS)).

YMC columns for poly aromatic hydrocarbons (PAH) are specifically designed for analysis of polynuclear aromatic hydrocarbons and provides the resolution necessary for a fast identification and quantification of PAHs (according to EPA).

YMC PAH columns provide narrow symmetrical peak shapes and its resolving ability leads to the easy identification and quantification of PAHs. The optimised selectivity of YMC PAH columns results in a separation with enough separation between peaks for wavelength changes when using fluorescence detectors.

The exclusive use of C18 groups makes the hydrophobic interaction identical for all three types of J´sphere ODS packings; only the degree of hydrophobicity, i.e. the polarity, is varied.
In addition to the hydrophobic interaction, the surface siloxane groups of J’sphere ODS packings provide a pronounced H-bonding capacity contributing additional selectivity. The ability to interact strongly via H-bonding creates the opportunity to make use of an additional degree of freedom in selectivity. The “controlled hydrogen bonding capacity" of J’sphere ODS packings represents an efficient tool for the chromatographic discrimination of closely related compounds presenting only minor molecular differences.