YMC*Gel HG-series (RP/NP/SEC Phases)

YMC*Gel HG-series (RP/NP/SEC Phases)

High Grade Silica Phases for Preparative HPLC

YMC*Gel HG-series (RP/NP/SEC Phases)

    Particle Technology

    YMC has achieved considerable improvements in the manufacture of its classical silica base. This has given rise to an improved generation of stationary phases with superior physical attributes: YMC*Gel High Grade (HG)-series.

    Due to its improved mechanical stability and its more uniform pore and particle size distribution the benefits of YMC*Gel HG-series products are:

    • Higher sample load
    • Less backpressure
    • Longer column usage
    • More repacking times possible
    • More efficient column packing
    C8-HG (Octyl)
    C4-HG (Butyl)
    Phase Code AAG AQG OCG BUG
    Modification C18 C18 C8 C4
    Pore Sizes [nm / Å] 12, 20, 30 /
    120, 200, 300
    8, 12, 20 /
    80, 120, 200
    12, 20, 30 /
    120, 200, 300
    12, 20, 30 /
    120, 200, 300
    Surface Area [m²/g] 330, 175, 100 510, 330, 175, 100 330, 175, 100 330, 175, 100
    Particle Sizes [µm] 10, 15, 20, 50
    Carbon Load 17, 12, 7% 15, 14, 10% 10, 7, 4% 7, 5, 3%
    pH Range 2-7.5


    TMS-HG (C1)
    Ph-HG (Phenyl)
    NH2-HG (Amino)
    Phase Code TMG PHG NHG
    Modification Trimethylsilane Phenyl Aminopropyl
    Pore Sizes [nm / Å] 12, (20, 30) /
    120, (200, 300)
    12, (20, 30) /
    120, (200, 300)
    12, (20, 30) /
    120, (200, 300)
    Surface Area [m²/g] 330, (175, 100) 330, (175, 100) 330, (175, 100)
    Particle Sizes [µm9 10, 15, 20, 50 10, 15, 20, 50 10, 15, 20, 50
    Carbon Load 4% 9% 3%
    pH Range 2-7.5 2-7.5 2-7.5


    CN-HG (Cyano)
    SIL-HG (Silica)
    Phase Code CNG DLG SLG
    Modification Cyanopropyl 1,2-Dihydroxypropyl -
    Pore Sizes
    [nm / Å]
    12, (20, 30) /
    120, (200, 300)
    12, 20, 30 /
    120, 200, 300
    6; 8; 12, 20, 30 /
    60; 80; 120, 200, 300
    Surface Area [m²/g] 330, (175, 100) 330, 175, 100 450; 510; 330, 175, 100
    Particle Sizes [µm] 10, 15, 20, 50 10, 15, 20, 50 10, 15, 20, 50
    Carbon Load 7% - -
    pH Range 2-7.5 2-7.5 -


      YMC*Gel SIL (Silica) YMCbasic YMC Omega
    Phase Code SL BA OMG
    Modification - C8 proprietary
    Pore Sizes [nm / Å]
    6, 12 / 60, 120 20 / 200 proprietary
    Surface Area [m²/g] 450, 330 175 proprietary
    Particle Sizes [µm] 75, 150 10, 15, 20 10, 20, 50
    Carbon Load - 7% 15%
    pH Range - 2-7.5 2-7.5


    YMC*Gel ODS-A-HG
    Phase Code AAG
    Modification C18
    Pore Sizes 12, 20, 30 nm / 120, 200, 300 Å
    Surface Area 330, 175, 100 m2/g
    Particle Sizes 10, 15, 20, 50 µm
    Carbon Load 17, 12, 7%
    pH Range 2-7.5


    YMC*Gel ODS-A-HG is YMC’s versatile octadecylsilane (ODS) C18 reversed phase packing material, suitable for a wide variety of applications. Due to its excellent performance and reproducibility it is a fully scalable C18 phase for large-scale preparative purification processes.

    Phase Code AQG
    Modification C18
    Pore Sizes 8; 12, 20, nm / 80; 120, 200, Å
    Surface Area 510; 330, 175, 100 m2/g
    Particle Sizes 10, 15, 20, 50 µm
    Carbon Load 15, 14, 10%
    pH Range 2-7.5


    YMC*Gel ODS-AQ-HG is a C18 reversed phase silica-based HPLC packing material specifically designed for use in 100% aqueous eluents. As a result of the proprietary derivatisation process, YMC*Gel ODS-AQ-HG exhibits a different selectivity to that of traditional C18 stationary phases. This difference in selectivity of YMC*Gel ODS-AQ-HG can be used to advantage for HPLC separations, which are difficult to achieve with conventional C18 columns, especially for polar compounds.

    YMC*Gel C8-HG (Octyl)
    Phase Code OCG
    Modification C8
    Pore Sizes 12, 20, 30 nm / 120, 200, 300 Å
    Surface Area 330, 175, 100 m2/g
    Particle Sizes 10, 15, 20, 50 µm
    Carbon Load 10, 7, 4%
    pH Range 2-7.5


    YMC*Gel C8-HG is one of YMC’s most versatile bonded phases and an excellent alternative to C18 selectivities. Due to its moderate hydrophobicity, YMC*Gel C8-HG is well suited for the separation of hydrophobic compounds which are too strongly retained on C18 phases or for samples that require greater retention than that provided by C4 packings. Compared to C18 phases, retention times of non-polar compounds will be lower on C8 material due to the reduced carbon load.

    YMC*Gel C4-HG (Butyl)
    Phase Code BUG
    Modification C4
    Pore Sizes 12, 20, 30 nm / 120, 200, 300 Å
    Surface Area 330, 175, 100 m2/g
    Particle Sizes 10, 15, 20, 50 µm
    Carbon Load 7, 5, 3%
    pH Range 2-7.5


    Due to shorter alkyl chains YMC*Gel C4-HG has a lower hydrophobicity than both C18 and C8 phases. As a result retention times for non-polar samples tend to be shorter on YMC*Gel C4-HG, making it an ideal choice for faster separations.

    YMC*Gel TMS-HG (C1)
    Phase Code TMG
    Modification Trimethylsilane
    Pore Sizes 12, (20, 30) nm / 120, (200, 300) Å
    Surface Area 330, (175, 100) m2/g
    Particle Sizes 10, 15, 20, 50 µm
    Carbon Load 4%
    pH Range 2-7.5


    YMC*Gel TMS-HG shows the lowest retention due to hydrophobic interaction of all reversed phase packing materials. It is useful for fast separations of highly hydrophobic samples that exhibit strong retention characteristics and are difficult or impossible to separate on conventional reversed phase packings. In addition, YMC*Gel TMS-HG can sometimes achieve greater retention and better separations of hydrophilic compounds than other reversed phase columns.

    YMC*Gel Ph-HG (Phenyl)
    Phase Code PHG
    Modification Phenyl
    Pore Sizes 12, (20, 30) nm / 120, (200, 300) Å
    Surface Area 330, (175, 100) m2/g
    Particle Sizes 10, 15, 20, 50 µm
    Carbon Load 9%
    pH Range 2-7.5


    YMC*Gel Ph-HG (Phenyl) is a high density bonded phase (9% carbon load on 12 nm silica) and is fully endcapped. This results in a superior bonded phase with proven performance and exceptional lifetime for a phenyl reversed phase column.

    YMC*Gel NH2-HG (Amino)
    Phase Code NHG
    Modification Aminopropyl
    Pore Sizes 12, (20, 30) nm / 120, (200, 300) Å
    Surface Area 330, (175, 100) m2/g
    Particle Sizes 10, 15, 20, 50 µm
    Carbon Load 3%
    pH Range 2-7.5


    YMC*Gel NH2-HG is specifically used for the analysis of carbohydrate-type materials under aqueous normal phase elution conditions. It can also be used in place of silica for conventional normal phase chromatography using nonpolar solvents and for HILIC separations of highly polar compounds.

    YMC*Gel CN-HG (Cyano)
    Phase Code CNG
    Modification Cyanopropyl
    Pore Sizes 12, (20, 30) nm / 120, (200, 300) Å
    Surface Area 330, (175, 100) m2/g
    Particle Sizes 10, 15, 20, 50 µm
    Carbon Load 7%
    pH Range 2-7.5


    Cyano phases are the most polar and least retentive of all reversed phase packings. Extremely hydrophobic compounds, which do not elute on standard C18 and C8 packings with typical reversed phase eluents, can be separated using cyano phases. Separations using normal phase, reversed phase and HILIC conditions can be carried out using this material.

    YMC*Gel Diol-HG
    Phase Code DLG
    Modification 1,2-Dihydroxypropyl
    Pore Sizes 12, 20, 30 nm / 120, 200, 300 Å
    Surface Area 330, 175, 100 m2/g
    Particle Sizes 10, 15, 20, 50 µm
    pH Range 2-7.5


    The silica-based YMC*Gel Diol-HG is a rugged and efficient normal phase, reversed phase or size exclusion material. It is generally used for the separation of biomolecules and pharmaceuticals. As the non-specific adsorptive sites have been eliminated it exhibits better performance characteristics for size separations than nonbonded silica. YMC*Gel Diol-HG is available in four porosities: 6, 12, 20 and 30 nm. Diol- 12 is most suitable for the separation of peptides or oligosaccharides with molecular weights of 10,000 or less, whereas Diol-20, and -30 (either used individually or in combination) are suitable for separations of proteins and other water-soluble compounds with molecular weights of 10,000 to several hundred thousands.

    YMC*Gel SIL-HG (Silica)/YMC*Gel SIL (Silica)
    Phase Code SLG SL
    Pore Sizes

    6; 8; 12, 20, 30 nm /

    60; 80; 120, 200, 300 Å

    6; 12 nm /

    60; 120Å
    Surface Area 450; 510; 330, 175, 100 m2/g 450; 330 m2/g
    Particle Sizes 10, 15, 20, 50 µm 75, 150 µm
    pH Range 2-7.5


    YMC*Gel SIL-HG is a fully scalable, high purity silica gel, which provides excellent batch-to-batch reproducibility and high sample recoveries. The totally porous spherical particles are mechanically and chemically stable, yet provide high surface area for greater sample loading and increased resolution.

    Phase Code
    Modification C8
    Pore Sizes 20 nm / 200 Å
    Surface Area 175 m2/g
    Particle Sizes 10, 15, 20 µm
    Carbon Load 7%
    pH Range 2-7.5


    YMCbasic is a unique reversed-phase column designed for analysis of pharmaceuticals and other basic compounds. YMCbasic utilises a novel silica synthesis and state-of-art silane bonding to create a column which gives true reversed-phase character, high resolution and excellent peak shape for the analysis of basic compounds.

    YMC Omega
    Phase Code
    Modification proprietary
    Pore Sizes proprietary
    Surface Area proprietary
    Particle Sizes 10, 20, 50 µm
    Carbon Load 15%
    pH Range 2-7.5


    YMC Omega has been specially designed for process-scale production of polyunsaturated fatty acids (PUFA’s) in a high purity. This new stationary phase enables economical production of fatty acids and increases the effectiveness and profitability of the preparative HPLC purification of omega-3 and omega-6 fatty acids.

    Improved Silica Base for Better Performance

    Improvements in the production process of the base silica has led to particles with higher mechanical stability and more uniform particle and pore size distribution (see microscopy images below).



    Tangible Improvements for your Process

    A narrower particle size distribution with lower tendency for the HG-silica material to produce fines translates directly into a reduced backpressure of preparative processes. On average a 7% backpressure reduction can be seen, which increases dramatically with each repacking step.

    Impact of Pore Size Differences

    YMC*Gel is available in a variety of different pore sizes. Pore sizes are usually matched to sample molecule sizes. Pore sizes can also be used to adjust ligand density and hence retention characteristics of a bonded phase, since the size of the pores also affects the total media surface area in a packed column.

    100% Aqueous Conditions with YMC*Gel ODS-AQ-HG
    Large Scale Purification on YMC*Gel ODS-AQ-HG
    Discover optimum selectivity

    The basis for every successful separation is the selection of the appropriate stationary phase. YMC offers one of the world‘s largest portfolios of selectivities, designed to handle even the most demanding separations.

    Title Document Type Language Phase Type Download
    YMC*Gel HG-series Brochure E
    YMC*Gel ODS-A-HG Care and Use Care and Use Instructions E
    MSDS Silica based NP/RP Bulk MSDS E
    Bulk Packing Material for Preparative Chromatography Overview E

    Request Now

    Please contact YMC for pricing or specific solutions for your purification process.

    Michael Ostendorf

    Product Manager Bulk Media


    ph. +49 (0)2064 427-280

    Product Description
    AAG12S11 YMC*Gel ODS-A-HG, 12nm S10µm
    AAG12S16 YMC*Gel ODS-A-HG, 12nm S15µm
    AAG12S21 YMC*Gel ODS-A-HG, 12nm S20µm
    AAG12S50 YMC*Gel ODS-A-HG, 12nm S50µm
    AAG20S11 YMC*Gel ODS-A-HG, 20nm S10µm
    AAG20S16 YMC*Gel ODS-A-HG, 20nm S15µm
    AAG20S21 YMC*Gel ODS-A-HG, 20nm S20µm
    AAG30S11 YMC*Gel ODS-A-HG, 30nm S10µm
    AAG30S16 YMC*Gel ODS-A-HG, 30nm S15µm
    AAG30S21 YMC*Gel ODS-A-HG, 30nm S20µm
    AQG12S11 YMC*Gel ODS-AQ-HG, 12nm S10µm
    AQG12S16 YMC*Gel ODS-AQ-HG, 12nm S15µm
    AQG12S21 YMC*Gel ODS-AQ-HG, 12nm S20µm
    AQG12S50 YMC*Gel ODS-AQ-HG, 12nm S50µm
    AQG20S11 YMC*Gel ODS-AQ-HG, 20nm S10µm
    AQG20S16 YMC*Gel ODS-AQ-HG, 20nm S15µm
    AQG20S21 YMC*Gel ODS-AQ-HG, 20nm S20µm
    AQG30S11 YMC*Gel ODS-AQ-HG, 30nm S10µm
    AQG30S16 YMC*Gel ODS-AQ-HG, 30nm S15µm
    AQG30S21 YMC*Gel ODS-AQ-HG, 30nm S20µm
    BUG12S11 YMC*Gel C4-HG (Butyl), 12nm S10µm
    BUG12S16 YMC*Gel C4-HG (Butyl), 12nm S15µm
    BUG12S21 YMC*Gel C4-HG (Butyl), 12nm S20µm
    BUG12S50 YMC*Gel C4-HG (Butyl), 12nm S50µm
    BUG20S11 YMC*Gel C4-HG (Butyl), 20nm S10µm
    BUG20S16 YMC*Gel C4-HG (Butyl), 20nm S15µm
    BUG20S21 YMC*Gel C4-HG (Butyl), 20nm S20µm
    BUG30S11 YMC*Gel C4-HG (Butyl), 30nm S10µm
    BUG30S16 YMC*Gel C4-HG (Butyl), 30nm S15µm
    BUG30S21 YMC*Gel C4-HG (Butyl), 30nm S20µm
    CNG12S11 YMC*Gel CN-HG (Cyano), 12nm S10µm
    CNG12S16 YMC*Gel CN-HG (Cyano), 12nm S15µm
    CNG12S21 YMC*Gel CN-HG (Cyano), 12nm S20µm
    CNG12S50 YMC*Gel CN-HG (Cyano), 12nm S50µm
    CNG20S11 YMC*Gel CN-HG (Cyano), 20nm S10µm
    CNG20S16 YMC*Gel CN-HG (Cyano), 20nm S15µm
    CNG20S21 YMC*Gel CN-HG (Cyano), 20nm S20µm
    CNG30S11 YMC*Gel CN-HG (Cyano), 30nm S10µm
    CNG30S16 YMC*Gel CN-HG (Cyano), 30nm S15µm
    CNG30S21 YMC*Gel CN-HG (Cyano), 30nm S20µm
    DLG12S11 YMC*Gel Diol-HG, 12nm S10µm
    DLG12S16 YMC*Gel Diol-HG, 12nm S15µm
    DLG12S21 YMC*Gel Diol-HG, 12nm S20µm
    DLG12S50 YMC*Gel Diol-HG, 12nm S50µm
    DLG20S11 YMC*Gel Diol-HG, 20nm S10µm
    DLG20S16 YMC*Gel Diol-HG, 20nm S15µm
    DLG20S21 YMC*Gel Diol-HG, 20nm S20µm
    DLG30S11 YMC*Gel Diol-HG, 30nm S10µm
    DLG30S16 YMC*Gel Diol-HG, 30nm S15µm
    DLG30S21 YMC*Gel Diol-HG, 30nm S20µm
    NHG12S11 YMC*Gel NH2-HG (Amino), 12nm S10µm
    NHG12S16 YMC*Gel NH2-HG (Amino), 12nm S15µm
    NHG12S21 YMC*Gel NH2-HG (Amino), 12nm S20µm
    NHG12S50 YMC*Gel NH2-HG (Amino), 12nm S50µm
    NHG20S11 YMC*Gel NH2-HG (Amino), 20nm S10µm
    NHG20S16 YMC*Gel NH2-HG (Amino), 20nm S15µm
    NHG20S21 YMC*Gel NH2-HG (Amino), 20nm S20µm
    NHG30S11 YMC*Gel NH2-HG (Amino), 30nm S10µm
    NHG30S16 YMC*Gel NH2-HG (Amino), 30nm S15µm
    NHG30S21 YMC*Gel NH2-HG (Amino), 30nm S20µm
    OCG12S11 YMC*Gel C8-HG (Octyl), 12nm S10µm
    OCG12S16 YMC*Gel C8-HG (Octyl), 12nm S15µm
    OCG12S21 YMC*Gel C8-HG (Octyl), 12nm S20µm
    OCG12S50 YMC*Gel C8-HG (Octyl), 12nm S50µm
    OCG20S11 YMC*Gel C8-HG (Octyl), 20nm S10µm
    OCG20S16 YMC*Gel C8-HG (Octyl), 20nm S15µm
    OCG20S21 YMC*Gel C8-HG (Octyl), 20nm S20µm
    OCG30S11 YMC*Gel C8-HG (Octyl), 30nm S10µm
    OCG30S16 YMC*Gel C8-HG (Octyl), 30nm S15µm
    OCG30S21 YMC*Gel C8-HG (Octyl), 30nm S20µm
    PHG12S11 YMC*Gel Ph-HG (Phenyl), 12nm S10µm
    PHG12S16 YMC*Gel Ph-HG (Phenyl), 12nm S15µm
    PHG12S21 YMC*Gel Ph-HG (Phenyl), 12nm S20µm
    PHG12S50 YMC*Gel Ph-HG (Phenyl), 12nm S50µm
    PHG20S11 YMC*Gel Ph-HG (Phenyl), 20nm S10µm
    PHG20S16 YMC*Gel Ph-HG (Phenyl), 20nm S15µm
    PHG20S21 YMC*Gel Ph-HG (Phenyl), 20nm S20µm
    PHG30S11 YMC*Gel Ph-HG (Phenyl), 30nm S10µm
    PHG30S16 YMC*Gel Ph-HG (Phenyl), 30nm S15µm
    PHG30S21 YMC*Gel Ph-HG (Phenyl), 30nm S20µm
    SLG12S11 YMC*Gel SIL-HG, 12nm S10µm
    SLG12S16 YMC*Gel SIL-HG, 12nm S15µm
    SLG12S21 YMC*Gel SIL-HG, 12nm S20µm
    SLG12S50 YMC*Gel SIL-HG, 12nm S50µm
    SLG20S11 YMC*Gel SIL-HG, 20nm S10µm
    SLG20S16 YMC*Gel SIL-HG, 20nm S15µm
    SLG20S21 YMC*Gel SIL-HG, 20nm S20µm
    SLG30S11 YMC*Gel SIL-HG, 30nm S10µm
    SLG30S16 YMC*Gel SIL-HG, 30nm S15µm
    SLG30S21 YMC*Gel SIL-HG, 30nm S20µm
    TMG12S11 YMC*Gel TMS-HG (C1), 12nm S10µm
    TMG12S16 YMC*Gel TMS-HG (C1), 12nm S15µm
    TMG12S21 YMC*Gel TMS-HG (C1), 12nm S20µm
    TMG12S50 YMC*Gel TMS-HG (C1), 12nm S50µm
    TMG20S11 YMC*Gel TMS-HG (C1), 20nm S10µm
    TMG20S16 YMC*Gel TMS-HG (C1), 20nm S15µm
    TMG20S21 YMC*Gel TMS-HG (C1), 20nm S20µm

    Related Categories


    • Michael Ostendorf
    • Product Manager
    • Bulk Media
    • ph. +49 (0)2064 427-280