Method Development Strategies

Method Development Strategies


Whitepaper for Method Development
Strategies for Preparative LC

The objectives for method developers in preparative LC are:

Purification and isolation of a target compound with a maximum sample amount in the shortest cycle time under cost pressure. Whereas isolation focuses on the scale up of mg- to g-units, the production scale needs to achieve up to kilograms or even tons.


The most comprehensive approach for method development in preparative LC is the so-called linear scale-up, which consist of:

  1. Method development at analytical scale
  2. Loadability studies on analytical scale
  3. Scale-up to preparative process
  4. Regulatory Affairs Support


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  • Michael Ostendorf
  • Product Manager
  • Bulk Media
  • ph. +49 (0)2064 427-270