YMC*Gel HG-series

YMC*Gel HG-series

High Grade Silica Phases for Preparative HPLC

YMC*Gel HG-series

    Particle Technology

    YMC has achieved considerable improvements in the manufacture of its classical silica base. This has given rise to an improved generation of stationary phases with superior physical attributes: YMC*Gel High Grade (HG)-series.

    Due to its improved mechanical stability and its more uniform pore and particle size distribution the benefits of YMC*Gel HG-series products are:

    • Higher sample load
    • Less backpressure
    • Longer column usage
    • More repacking times possible
    • More efficient column packing

    Available Phases are:

    • YMC*Gel ODS-A-HG
    • YMC*Gel ODS-AQ-HG
    • YMC*Gel C8-HG (Octyl)
    • YMC*Gel C4-HG (Butyl)
    • YMC*Gel TMS-HG (C1)
    • YMC*Gel Ph-HG (Phenyl)
    • YMC*Gel NH2-HG (Amino)
    • YMC*Gel CN-HG (Cyano)
    • YMCbasic
    • YMC Omega
    Specifications
      YMC*Gel
    ODS-A-HG
    YMC*Gel
    ODS-AQ-HG
    YMC*Gel
    C8-HG (Octyl)
    YMC*Gel
    C4-HG (Butyl)
    Phase Code AAG AQG OCG BUG
    Modification C18 C18 C8 C4
    Pore Sizes [nm / Å] 12, 20, 30 /
    120, 200, 300
    8, 12, 20 /
    80, 120, 200
    12, 20, 30 /
    120, 200, 300
    12, 20, 30 /
    120, 200, 300
    Surface Area [m²/g] 330, 175, 100 510, 330, 175, 100 330, 175, 100 330, 175, 100
    Particle Sizes [µm] 10, 15, 20, 50
    Carbon Load 17, 12, 7% 15, 14, 10% 10, 7, 4% 7, 5, 3%
    pH Range 2-7.5

     

      YMC*Gel
    TMS-HG (C1)
    Phase Code TMG
    Modification Trimethylsilane
    Pore Sizes [nm / Å] 12, (20, 30) /
    120, (200, 300)
    Surface Area [m²/g] 330, (175, 100)
    Particle Sizes [µm9 10, 15, 20, 50
    Carbon Load 4%
    pH Range 2-7.5

     

      YMC*Gel
    CN-HG (Cyano)
    YMC*Gel
    Ph-HG (Phenyl)
    YMC*Gel
    NH2-HG (Amino)
    Phase Code CNG PHG NHG
    Modification Cyanopropyl Phenyl Aminopropyl
    Pore Sizes
    [nm / Å]
    12, (20, 30) /
    120, (200, 300)
    12, (20, 30) /
    120, (200, 300)
    12, (20, 30) /
    120, (200, 300)
    Surface Area [m²/g] 330, (175, 100) 330, (175, 100) 330, (175, 100)
    Particle Sizes [µm] 10, 15, 20, 50 10, 15, 20, 50 10, 15, 20, 50
    Carbon Load 7% 9% 3%
    pH Range 2-7.5 2-7.5 2-7.5

     

     

      YMCbasic YMC Omega
    Phase Code BA OMG
    Modification C8 proprietary
    Pore Sizes [nm / Å]
    20 / 200 proprietary
    Surface Area [m²/g] 175 proprietary
    Particle Sizes [µm] 10, 15, 20 10, 20, 50
    Carbon Load 7% 15%
    pH Range 2-7.5 2-7.5

     

    YMC*Gel ODS-A-HG
    Phase Code AAG
    Modification C18
    Pore Sizes 12, 20, 30 nm / 120, 200, 300 Å
    Surface Area 330, 175, 100 m2/g
    Particle Sizes 10, 15, 20, 50 µm
    Carbon Load 17, 12, 7%
    pH Range 2-7.5

     

    YMC*Gel ODS-A-HG is YMC’s versatile octadecylsilane (ODS) C18 reversed phase packing material, suitable for a wide variety of applications. Due to its excellent performance and reproducibility it is a fully scalable C18 phase for large-scale preparative purification processes.

    YMC*Gel ODS-AQ-HG
    Phase Code AQG
    Modification C18
    Pore Sizes 8; 12, 20, nm / 80; 120, 200, Å
    Surface Area 510; 330, 175, 100 m2/g
    Particle Sizes 10, 15, 20, 50 µm
    Carbon Load 15, 14, 10%
    pH Range 2-7.5

     

    YMC*Gel ODS-AQ-HG is a C18 reversed phase silica-based HPLC packing material specifically designed for use in 100% aqueous eluents. As a result of the proprietary derivatisation process, YMC*Gel ODS-AQ-HG exhibits a different selectivity to that of traditional C18 stationary phases. This difference in selectivity of YMC*Gel ODS-AQ-HG can be used to advantage for HPLC separations, which are difficult to achieve with conventional C18 columns, especially for polar compounds.

    YMC*Gel C8-HG (Octyl)
    Phase Code OCG
    Modification C8
    Pore Sizes 12, 20, 30 nm / 120, 200, 300 Å
    Surface Area 330, 175, 100 m2/g
    Particle Sizes 10, 15, 20, 50 µm
    Carbon Load 10, 7, 4%
    pH Range 2-7.5

     

    YMC*Gel C8-HG is one of YMC’s most versatile bonded phases and an excellent alternative to C18 selectivities. Due to its moderate hydrophobicity, YMC*Gel C8-HG is well suited for the separation of hydrophobic compounds which are too strongly retained on C18 phases or for samples that require greater retention than that provided by C4 packings. Compared to C18 phases, retention times of non-polar compounds will be lower on C8 material due to the reduced carbon load.

    YMC*Gel C4-HG (Butyl)
    Phase Code BUG
    Modification C4
    Pore Sizes 12, 20, 30 nm / 120, 200, 300 Å
    Surface Area 330, 175, 100 m2/g
    Particle Sizes 10, 15, 20, 50 µm
    Carbon Load 7, 5, 3%
    pH Range 2-7.5

     

    Due to shorter alkyl chains YMC*Gel C4-HG has a lower hydrophobicity than both C18 and C8 phases. As a result retention times for non-polar samples tend to be shorter on YMC*Gel C4-HG, making it an ideal choice for faster separations.

    YMC*Gel TMS-HG (C1)
    Phase Code TMG
    Modification Trimethylsilane
    Pore Sizes 12, (20, 30) nm / 120, (200, 300) Å
    Surface Area 330, (175, 100) m2/g
    Particle Sizes 10, 15, 20, 50 µm
    Carbon Load 4%
    pH Range 2-7.5

     

    YMC*Gel TMS-HG shows the lowest retention due to hydrophobic interaction of all reversed phase packing materials. It is useful for fast separations of highly hydrophobic samples that exhibit strong retention characteristics and are difficult or impossible to separate on conventional reversed phase packings. In addition, YMC*Gel TMS-HG can sometimes achieve greater retention and better separations of hydrophilic compounds than other reversed phase columns.

    Improved Silica Base for Better Performance

    Improvements in the production process of the base silica has led to particles with higher mechanical stability and more uniform particle and pore size distribution (see microscopy images below).

     

     

    Tangible Improvements for your Process

    A narrower particle size distribution with lower tendency for the HG-silica material to produce fines translates directly into a reduced backpressure of preparative processes. On average a 7% backpressure reduction can be seen, which increases dramatically with each repacking step.

    Impact of Pore Size Differences

    YMC*Gel is available in a variety of different pore sizes. Pore sizes are usually matched to sample molecule sizes. Pore sizes can also be used to adjust ligand density and hence retention characteristics of a bonded phase, since the size of the pores also affects the total media surface area in a packed column.

    100% Aqueous Conditions with YMC*Gel ODS-AQ-HG
    Large Scale Purification on YMC*Gel ODS-AQ-HG
    Discover optimum selectivity

    The basis for every successful separation is the selection of the appropriate stationary phase. YMC offers one of the world‘s largest portfolios of selectivities, designed to handle even the most demanding separations.

    Title Document Type Language Phase Type Download
    YMC*Gel HG Packing Materials Brochure E
    YMC*Gel ODS-A-HG Care and Use Care and Use Instructions E
    MSDS Silica based NP/RP Bulk MSDS E
    Bulk Packing Materials for Preparative Chromatography Overview E

    Request Now

    Please contact YMC for pricing or specific solutions for your purification process.

    Michael Ostendorf

    Product Manager Bulk Media

     

    ph. +49 (0)2064 427-280

    Product Description
    AAG12S11 YMC*Gel ODS-A-HG, 12nm S10µm
    AAG12S16 YMC*Gel ODS-A-HG, 12nm S15µm
    AAG12S21 YMC*Gel ODS-A-HG, 12nm S20µm
    AAG12S50 YMC*Gel ODS-A-HG, 12nm S50µm
    AAG20S11 YMC*Gel ODS-A-HG, 20nm S10µm
    AAG20S16 YMC*Gel ODS-A-HG, 20nm S15µm
    AAG20S21 YMC*Gel ODS-A-HG, 20nm S20µm
    AAG30S11 YMC*Gel ODS-A-HG, 30nm S10µm
    AAG30S16 YMC*Gel ODS-A-HG, 30nm S15µm
    AAG30S21 YMC*Gel ODS-A-HG, 30nm S20µm
    AQG12S11 YMC*Gel ODS-AQ-HG, 12nm S10µm
    AQG12S16 YMC*Gel ODS-AQ-HG, 12nm S15µm
    AQG12S21 YMC*Gel ODS-AQ-HG, 12nm S20µm
    AQG12S50 YMC*Gel ODS-AQ-HG, 12nm S50µm
    AQG20S11 YMC*Gel ODS-AQ-HG, 20nm S10µm
    AQG20S16 YMC*Gel ODS-AQ-HG, 20nm S15µm
    AQG20S21 YMC*Gel ODS-AQ-HG, 20nm S20µm
    AQG30S11 YMC*Gel ODS-AQ-HG, 30nm S10µm
    AQG30S16 YMC*Gel ODS-AQ-HG, 30nm S15µm
    AQG30S21 YMC*Gel ODS-AQ-HG, 30nm S20µm
    BUG12S11 YMC*Gel C4-HG (Butyl), 12nm S10µm
    BUG12S16 YMC*Gel C4-HG (Butyl), 12nm S15µm
    BUG12S21 YMC*Gel C4-HG (Butyl), 12nm S20µm
    BUG12S50 YMC*Gel C4-HG (Butyl), 12nm S50µm
    BUG20S11 YMC*Gel C4-HG (Butyl), 20nm S10µm
    BUG20S16 YMC*Gel C4-HG (Butyl), 20nm S15µm
    BUG20S21 YMC*Gel C4-HG (Butyl), 20nm S20µm
    BUG30S11 YMC*Gel C4-HG (Butyl), 30nm S10µm
    BUG30S16 YMC*Gel C4-HG (Butyl), 30nm S15µm
    BUG30S21 YMC*Gel C4-HG (Butyl), 30nm S20µm
    CNG12S11 YMC*Gel CN-HG (Cyano), 12nm S10µm
    CNG12S16 YMC*Gel CN-HG (Cyano), 12nm S15µm
    CNG12S21 YMC*Gel CN-HG (Cyano), 12nm S20µm
    CNG12S50 YMC*Gel CN-HG (Cyano), 12nm S50µm
    CNG20S11 YMC*Gel CN-HG (Cyano), 20nm S10µm
    CNG20S16 YMC*Gel CN-HG (Cyano), 20nm S15µm
    CNG20S21 YMC*Gel CN-HG (Cyano), 20nm S20µm
    CNG30S11 YMC*Gel CN-HG (Cyano), 30nm S10µm
    CNG30S16 YMC*Gel CN-HG (Cyano), 30nm S15µm
    CNG30S21 YMC*Gel CN-HG (Cyano), 30nm S20µm
    NHG12S11 YMC*Gel NH2-HG (Amino), 12nm S10µm
    NHG12S16 YMC*Gel NH2-HG (Amino), 12nm S15µm
    NHG12S21 YMC*Gel NH2-HG (Amino), 12nm S20µm
    NHG12S50 YMC*Gel NH2-HG (Amino), 12nm S50µm
    NHG20S11 YMC*Gel NH2-HG (Amino), 20nm S10µm
    NHG20S16 YMC*Gel NH2-HG (Amino), 20nm S15µm
    NHG20S21 YMC*Gel NH2-HG (Amino), 20nm S20µm
    NHG30S11 YMC*Gel NH2-HG (Amino), 30nm S10µm
    NHG30S16 YMC*Gel NH2-HG (Amino), 30nm S15µm
    NHG30S21 YMC*Gel NH2-HG (Amino), 30nm S20µm
    OMG99S11 YMC-Omega, S10µm
    OMG99S21 YMC-Omega, S20µm
    PHG12S11 YMC*Gel Ph-HG (Phenyl), 12nm S10µm
    PHG12S16 YMC*Gel Ph-HG (Phenyl), 12nm S15µm
    PHG12S21 YMC*Gel Ph-HG (Phenyl), 12nm S20µm
    PHG12S50 YMC*Gel Ph-HG (Phenyl), 12nm S50µm
    PHG20S11 YMC*Gel Ph-HG (Phenyl), 20nm S10µm
    PHG20S16 YMC*Gel Ph-HG (Phenyl), 20nm S15µm
    PHG20S21 YMC*Gel Ph-HG (Phenyl), 20nm S20µm
    PHG30S11 YMC*Gel Ph-HG (Phenyl), 30nm S10µm
    PHG30S16 YMC*Gel Ph-HG (Phenyl), 30nm S15µm
    PHG30S21 YMC*Gel Ph-HG (Phenyl), 30nm S20µm

    Related Categories

    Contact

    • Michael Ostendorf
    • Product Manager
    • Bulk Media
    • ph. +49 (0)2064 427-280