Covid-19 Information Source

Covid-19 Information Source

Covid-19 YMC Information Source

    Covid-19 Related YMC Solutions

    YMC is committed to the best support we can provide for our users. In these pages you will find helpful application notes covering substances used in current Covid-19 research. You can also discover application notes for RNA separations as used in several vaccine approaches.

    Furthermore, we have put together a selection of publications on the substances used in Covid-19 treatment. You can see directly which YMC column used in the publication or the YMC column recommended for the applied method.

    For any further request, please contact us directly:

     

    • Application Notes for substances in Covid-19 research
    • Application Notes for RNA analysis useful for vaccine production
    • Selection of publications covering Covid-19 related compounds
    • YMC column recommendations for the methods used
    Application Columns Compound name
    Adrenocorticosteroids J'sphere ODS-H80 Hydrocortisone Cortisone Methylprednisolone Betamethasone Dexamethasone Corticosterone Beclomethasone Triamcinolone acetonide
    Chloroquine CHIRAL ART Amylose-SA Chloroquine
    HPLC Analysis of Oligonucleotides Using YMC’s Non-porous AEX Columns BioPro IEX QF Synthetic oligonucleotides (Single-strand RNA, Single-strand DNA)
    Hydroxychloroquine Sulfate Tablets (USP 37th) YMC-Triart C18 Hydroxychloroquine sulfate Chloroquine phosphate
    LC/MS analysis of oligonucleotides (siRNA) YMC-Triart C18 5'-GU ACG CGG AAU ACU UCG AdTdT-3' (20 nt) 5'-CGU ACG CGG AAU ACU UCG AdTdT-3' (21 nt)
    LC/MS analysis of oligonucleotides (miRNA) YMC-Triart C18 5'-pUGG AGU GUG ACA AUG GUG UUG-3' (21 nt) 5'-pUGG AGU GUG ACA AUG GUG UUG U-3' (22 nt)
    Optimisation of oligonucleotide separations using YMC´s non porous anion exchanger BioPro IEX QF BioPro IEX QF Single strand DNA Single Strand RNA Single Strand 2'-OMe RNA
    Optimisation of phosphorothioate oligonucleotide separation using BioPro IEX QF BioPro IEX QF Phosphorothioated Single Strand RNA
    Phosphorothioate oligonucleotides YMC-Triart C18 Phosphorothioated RNA 20 mer, Phosphorothioated RNA 21 mer
    Synthetic oligonucleotides (Single-strand RNA) BioPro IEX QF 5’-U(M)C(M)A(M)U(M)C(M)A(M)C(M)A(M)C(M) U(M)G(M)A(M)A(M)U(M)A(M)C(M)C(M)A(M)A(M)U(M)-3’ (20 mer) 5’-G(M)U(M)C(M)A(M)U(M)C(M)A(M)C(M)A(M)C(M)U(M) G(M)A(M)A(M)U(M)A(M)C(M)C(M)A(M)A(M)U(M)-3’ (21 mer)
    UHPLC separation of hydroxychloroquine and chloroquine YMC-Triart C18 Hydroxychloroquine sulfate Chloroquine phosphate
    Substance(s) evaluated Publication Titel
    Used/Recommended
    YMC Column
    Reference
    Fluoxetine
    Simultaneous Determination of Olanzapine and Fluoxetine by HPLC
    YMC-Triart C18 (5 µm) 150 x 4.6 mm ID (TA12S05-1546PTH)
    B. V. Reddy et al., Chromatographia 66 (2007) 111-114.
    Dexamethasone
    Development and validation of HPLC method for analysis of dexamethasone acetate in microemulsions
    YMC-Triart C18 (5 µm) 250 x 4.6 mm ID (TA12S05-2546PTH)
    M. C. Cocenza Urban et al., Brazilian Journal of
    Pharmaceutical Sciences
    vol. 45, 1 (2009) 87-92.
    Dexamethasone
    Dexamethasone Monograph
    YMC-Triart C18 (5 µm) 150 x 4.6 mm ID (TA12S05-1546PTH)
    Ph. Eur. 7 (2010)
    Ritonavir
    United States Patent: Ritonavir Bis-Hydrochloride
    YMC-Pack C4 (3 µm) 150 x 4.6 mm ID
    (BU12S03-1546WT)
    M. Acquasaliente et al. United States Patent, Patent No. US 8.598.216 B1 (2013).
    Ritonavir
    Development and Validation of a Simple, Sensitive, Selective and Stability-Indicating RP-UPLC Method for the Quantitative Determination of Ritonavir and Its Related Compounds
    YMC-Triart C18 (1.9 µm) 100 x 2.1 mm ID (TA12SP9-10Q1PT)
    S. Koppala et al., Journal of Chromatographic Science, 53 (2015) 662–675.
    Ritonavir
    Ritonavir Monograph
    YMC-Pack Pro C4 (3 µm) 150 x 4.6 mm ID (BS12S03-1546WT)
    Ph. Eur. 8 (2014)
    Lopinavir
    Lopinavir Monograph
    YMC-Triart C18 (3 µm) 250 x 4.6 mm ID (TA12S03-2546PTH)
    Ph. Eur. 8 (2014)
    Ritonavir, Lopinavir
    RP-HPLC method for simultaneous estimation of antiretroviral drugs lopinavir and ritonavir in table dosage form
    YMC-Triart C18 (5 µm) 250 x 4.6 mm ID (TA12S05-2546PTH)
    I. Ponnilavarasan et al., Digest Journal of Nanomaterials and Biostructures Vol. 5, 3 (2010) 771-778.
    Fenofibrate
    Phase separation of supersaturated solution created from amorphous solid dispersions: Relevance to oral absorption
    J’sphere ODS-H80 (4 µm) 75 x 4.6 mm ID
    (JH08S04-L546WT)
    K. Kawakamia et al., European Journal of Pharmaceutics and Biopharmaceutics, 132 (2018) 146–156.
    Interferon alpha-2
    Study of aggregation, denaturation and reduction of interferon alpha-2 products by size-exclusion high-performance liquid chromatography with fluorescence detection and biological assays
    YMC-SEC MAB (3 µm) 300 x 8.0 mm ID
    (DLM25S05-3008WT) +
    YMC-Pack Diol-120 (5 µm) 300 x 8.0 mm ID
    (DL12S05-3008WT)
    A. Diress et al., Journal of Chromatography A, 1217 (2010) 3297–3306.
    Chloroquine
    Identification of Falsified Chloroquine Tablets in Africa at the Time of the COVID-19 Pandemic
    YMC-Triart C18 (5 µm) 250 x 4.0 mm ID
    (TA12S05-2504PTH) +
    YMC-Triart C18 (5 µm) 150 x 4.6 mm ID
    (TA12S05-1546PTH)
    G. Gnegel et al., American Journal of Tropical Medicine and Hygiene, 00 (2020) 1–4.
    Chloroquine
    In vitro Metabolic Stability Study of New Cyclen Based Antimalarial Drug Leads Using RP-HPLC and LC-MS/MS
    YMC-Triart C18 (5 µm) 150 x 4.6 mm ID
    (TA12S05-1546PTH) +
    YMC-Triart C18 (5 µm) 250 x 4.6 mm ID
    (TA12S05-2546PTH)
    A. V. Rudraraju et al., Modern Chemistry & Applications, 2 (2014) 129.
    Fingolimod
    Absorption and Disposition of the Sphingosine 1-Phosphate Receptor Modulator Fingolimod (FTY720) in Healthy Volunteers: A Case of Xenobiotic Biotransformation Following Endogenous Metabolic Pathways
    YMC-Triart C8 (3 µm) 50 x 4.6 mm ID TO12S03-0546PTH)
    M. Zollinger et al., Drug Metabolism and Disposition, 39:2 (2011) 199-207.
    Pirfenidone
    Development and Substantiation of a RP-HPLC Method for Monitoring of Impurities in Pirfenidone Drug Substance
    YMC-Triart C18 (5 µm) 250 x 4.6 mm ID
    (TA12S05-2546PTH)
    S. B. Bodempudi et al., American Journal of Analytical Chemistry, 6 (2015) 1019-1029.
    Favipiravir
    Alterations in favipiravir (T-705) pharmacokinetics and biodistribution in a hamster model of viral hemorrhagic fever
    YMC-Pack ODS-A (5 µm) 250 x 4.6 mm ID
    (AA12S05-2546WT)
    B. B. Gowen et al., Antiviral Research, 121 (2015) 132–137.
    Penciclovir
    Simultaneous determination of aciclovir, ganciclovir, and penciclovir in human plasma by high-performance liquid chromatography with fluorescence detection
    YMC-Triart C18 (5 µm) 250 x 4.6 mm ID
    (TA12S05-2546PTH)
    Y. Dao et al., Journal of Chromatography B, 867 (2008) 270–276.
    Ribavirin
    HPLC–MS/MS method for the intracellular determination of ribavirin monophosphate and ribavirin triphosphate in CEMss cells
    YMC-Pack Pro C18 (3 µm) 100 x 1.0 mm ID
    (AS12S03-1001WT)
    M. Meléndez et al., Journal of Pharmaceutical and Biomedical Analysis, 49(5) (2012) 1233–1240.
    Nafamostat mesylate
    Identification of impurities in nafamostat mesylate using HPLC-IT-TOF/MS: A series of double-charged ions
    YMC-Triart C18 x2 (3 µm) 100 x 4.6 mm ID
    (2x TA12S03-1046PTH)
    Y. Zhang et al., Journal of Pharmaceutical Analysis (2020).

     

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