Covid-19 YMC Information Source
Covid-19 Related YMC Solutions
YMC is committed to the best support we can provide for our users. In these pages you will find helpful application notes covering substances used in current Covid-19 research. You can also discover application notes for RNA separations as used in several vaccine approaches.
Furthermore, we have put together a selection of publications on the substances used in Covid-19 treatment. You can see directly which YMC column used in the publication or the YMC column recommended for the applied method.
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- Application Notes for substances in Covid-19 research
- Application Notes for RNA analysis useful for vaccine production
- Selection of publications covering Covid-19 related compounds
- YMC column recommendations for the methods used
| Application | Columns | Compound name | |
| Adrenocorticosteroids | J'sphere ODS-H80 | Hydrocortisone Cortisone Methylprednisolone Betamethasone Dexamethasone Corticosterone Beclomethasone Triamcinolone acetonide | |
| Chloroquine | CHIRAL ART Amylose-SA | Chloroquine | |
| HPLC Analysis of Oligonucleotides Using YMC’s Non-porous AEX Columns | BioPro IEX QF | Synthetic oligonucleotides (Single-strand RNA, Single-strand DNA) | |
| Hydroxychloroquine Sulfate Tablets (USP 37th) | YMC-Triart C18 | Hydroxychloroquine sulfate Chloroquine phosphate | |
| LC/MS analysis of oligonucleotides (siRNA) | YMC-Triart C18 | 5'-GU ACG CGG AAU ACU UCG AdTdT-3' (20 nt) 5'-CGU ACG CGG AAU ACU UCG AdTdT-3' (21 nt) | |
| LC/MS analysis of oligonucleotides (miRNA) | YMC-Triart C18 | 5'-pUGG AGU GUG ACA AUG GUG UUG-3' (21 nt) 5'-pUGG AGU GUG ACA AUG GUG UUG U-3' (22 nt) | |
| Optimisation of oligonucleotide separations using YMC´s non porous anion exchanger BioPro IEX QF | BioPro IEX QF | Single strand DNA Single Strand RNA Single Strand 2'-OMe RNA | |
| Optimisation of phosphorothioate oligonucleotide separation using BioPro IEX QF | BioPro IEX QF | Phosphorothioated Single Strand RNA | |
| Phosphorothioate oligonucleotides | YMC-Triart C18 | Phosphorothioated RNA 20 mer, Phosphorothioated RNA 21 mer | |
| Synthetic oligonucleotides (Single-strand RNA) | BioPro IEX QF | 5’-U(M)C(M)A(M)U(M)C(M)A(M)C(M)A(M)C(M) U(M)G(M)A(M)A(M)U(M)A(M)C(M)C(M)A(M)A(M)U(M)-3’ (20 mer) 5’-G(M)U(M)C(M)A(M)U(M)C(M)A(M)C(M)A(M)C(M)U(M) G(M)A(M)A(M)U(M)A(M)C(M)C(M)A(M)A(M)U(M)-3’ (21 mer) | |
| UHPLC separation of hydroxychloroquine and chloroquine | YMC-Triart C18 | Hydroxychloroquine sulfate Chloroquine phosphate |
| Substance(s) evaluated | Publication Titel |
Used/Recommended
YMC Column
|
Reference |
| Fluoxetine |
Simultaneous Determination of Olanzapine and Fluoxetine by HPLC
|
YMC-Triart C18 (5 µm) 150 x 4.6 mm ID (TA12S05-1546PTH)
|
B. V. Reddy et al., Chromatographia 66 (2007) 111-114.
|
| Dexamethasone |
Development and validation of HPLC method for analysis of dexamethasone acetate in microemulsions
|
YMC-Triart C18 (5 µm) 250 x 4.6 mm ID (TA12S05-2546PTH)
|
M. C. Cocenza Urban et al., Brazilian Journal of
Pharmaceutical Sciences vol. 45, 1 (2009) 87-92. |
|
Dexamethasone
|
Dexamethasone Monograph
|
YMC-Triart C18 (5 µm) 150 x 4.6 mm ID (TA12S05-1546PTH)
|
Ph. Eur. 7 (2010)
|
|
Ritonavir
|
United States Patent: Ritonavir Bis-Hydrochloride
|
YMC-Pack C4 (3 µm) 150 x 4.6 mm ID
(BU12S03-1546WT)
|
M. Acquasaliente et al. United States Patent, Patent No. US 8.598.216 B1 (2013).
|
|
Ritonavir
|
Development and Validation of a Simple, Sensitive, Selective and Stability-Indicating RP-UPLC Method for the Quantitative Determination of Ritonavir and Its Related Compounds
|
YMC-Triart C18 (1.9 µm) 100 x 2.1 mm ID (TA12SP9-10Q1PT)
|
S. Koppala et al., Journal of Chromatographic Science, 53 (2015) 662–675.
|
|
Ritonavir
|
Ritonavir Monograph
|
YMC-Pack Pro C4 (3 µm) 150 x 4.6 mm ID (BS12S03-1546WT)
|
Ph. Eur. 8 (2014)
|
|
Lopinavir
|
Lopinavir Monograph
|
YMC-Triart C18 (3 µm) 250 x 4.6 mm ID (TA12S03-2546PTH)
|
Ph. Eur. 8 (2014)
|
|
Ritonavir, Lopinavir
|
RP-HPLC method for simultaneous estimation of antiretroviral drugs lopinavir and ritonavir in table dosage form
|
YMC-Triart C18 (5 µm) 250 x 4.6 mm ID (TA12S05-2546PTH)
|
I. Ponnilavarasan et al., Digest Journal of Nanomaterials and Biostructures Vol. 5, 3 (2010) 771-778.
|
|
Fenofibrate
|
Phase separation of supersaturated solution created from amorphous solid dispersions: Relevance to oral absorption
|
J’sphere ODS-H80 (4 µm) 75 x 4.6 mm ID
(JH08S04-L546WT)
|
K. Kawakamia et al., European Journal of Pharmaceutics and Biopharmaceutics, 132 (2018) 146–156.
|
|
Interferon alpha-2
|
Study of aggregation, denaturation and reduction of interferon alpha-2 products by size-exclusion high-performance liquid chromatography with fluorescence detection and biological assays
|
YMC-SEC MAB (3 µm) 300 x 8.0 mm ID
(DLM25S05-3008WT) +
YMC-Pack Diol-120 (5 µm) 300 x 8.0 mm ID
(DL12S05-3008WT)
|
A. Diress et al., Journal of Chromatography A, 1217 (2010) 3297–3306.
|
|
Chloroquine
|
Identification of Falsified Chloroquine Tablets in Africa at the Time of the COVID-19 Pandemic
|
YMC-Triart C18 (5 µm) 250 x 4.0 mm ID
(TA12S05-2504PTH) +
YMC-Triart C18 (5 µm) 150 x 4.6 mm ID
(TA12S05-1546PTH)
|
G. Gnegel et al., American Journal of Tropical Medicine and Hygiene, 00 (2020) 1–4.
|
|
Chloroquine
|
In vitro Metabolic Stability Study of New Cyclen Based Antimalarial Drug Leads Using RP-HPLC and LC-MS/MS
|
YMC-Triart C18 (5 µm) 150 x 4.6 mm ID
(TA12S05-1546PTH) +
YMC-Triart C18 (5 µm) 250 x 4.6 mm ID
(TA12S05-2546PTH)
|
A. V. Rudraraju et al., Modern Chemistry & Applications, 2 (2014) 129.
|
|
Fingolimod
|
Absorption and Disposition of the Sphingosine 1-Phosphate Receptor Modulator Fingolimod (FTY720) in Healthy Volunteers: A Case of Xenobiotic Biotransformation Following Endogenous Metabolic Pathways
|
YMC-Triart C8 (3 µm) 50 x 4.6 mm ID TO12S03-0546PTH)
|
M. Zollinger et al., Drug Metabolism and Disposition, 39:2 (2011) 199-207.
|
|
Pirfenidone
|
Development and Substantiation of a RP-HPLC Method for Monitoring of Impurities in Pirfenidone Drug Substance
|
YMC-Triart C18 (5 µm) 250 x 4.6 mm ID
(TA12S05-2546PTH)
|
S. B. Bodempudi et al., American Journal of Analytical Chemistry, 6 (2015) 1019-1029.
|
|
Favipiravir
|
Alterations in favipiravir (T-705) pharmacokinetics and biodistribution in a hamster model of viral hemorrhagic fever
|
YMC-Pack ODS-A (5 µm) 250 x 4.6 mm ID
(AA12S05-2546WT)
|
B. B. Gowen et al., Antiviral Research, 121 (2015) 132–137.
|
|
Penciclovir
|
Simultaneous determination of aciclovir, ganciclovir, and penciclovir in human plasma by high-performance liquid chromatography with fluorescence detection
|
YMC-Triart C18 (5 µm) 250 x 4.6 mm ID
(TA12S05-2546PTH)
|
Y. Dao et al., Journal of Chromatography B, 867 (2008) 270–276.
|
|
Ribavirin
|
HPLC–MS/MS method for the intracellular determination of ribavirin monophosphate and ribavirin triphosphate in CEMss cells
|
YMC-Pack Pro C18 (3 µm) 100 x 1.0 mm ID
(AS12S03-1001WT)
|
M. Meléndez et al., Journal of Pharmaceutical and Biomedical Analysis, 49(5) (2012) 1233–1240.
|
|
Nafamostat mesylate
|
Identification of impurities in nafamostat mesylate using HPLC-IT-TOF/MS: A series of double-charged ions
|
YMC-Triart C18 x2 (3 µm) 100 x 4.6 mm ID
(2x TA12S03-1046PTH)
|
Y. Zhang et al., Journal of Pharmaceutical Analysis (2020).
|
