YMC Chiral Bulk

YMC Chiral Bulk

20 μm and 10 μm materials in bulk - in multikilogram amounts

YMC Chiral Bulk

    General Information

    Preparative Scale YMC CHIRAL is suitable both for the conventional column separations and also for dynamic axial compression (DAC) columns and simulated moving bed (SMB) systems.

    YMC CHIRAL bulk material is available up to several hundred kilograms with YMC's well known high quality, reproducibility and technical support. It provides a significant tool for downstream processing at pilot production scale.

    Combined with the surprising cost-efficiency, YMC CHIRAL will be of interest in developing or up-scaling chiral purification processes. In addition, method development is made easier by use of scouting columns for selectivity screening.

    Scale Up
    Column Packing: YMC CHIRAL Prep CD ST (10 μm, 12 nm)
    Preparative Seperations
    Compound Phase Sample Load Optical Purity Collection Fraction 1 Recovery Fraction 1
    1 PM 100 mg in 10 mL >99.9% 49.6 mg 99.2%
    2 ST 100 mg in 10 mL >99.9% 47.7 mg 94.8%
    3 PM 200 mg in 5 mL >99.9% 96.3 mg 96.3%
    3 PM 250 mg in 5 mL >99.9% 114.2 mg 91.3%

     

     

    Column Size : 250 x 20 mm i.d. (10 μm, 12 nm)
    Eluents: (1) 25 mM KH2PO4 / MeOH (20/80)
    (2) 20 mM AcNH4 + ACN/MeOH (70/30)
    (4) 0.5 M NaCIO4 / ACN (90/10)
    Flow Rate: 9 mL/min
    Pressure: 1 bar

     

    Specifications
      CHIRAL ART Amylose-C CHIRAL ART Cellulose-C CHIRAL ART Amylose-SA CHIRAL ART Cellulose-SB
    CHIRAL ART
    Cellulose-SC
    Chiral Selector Amylose Cellulose Amylose Cellulose Cellulose
     
    tris (3,5-dimethylphenyl-
    carbamate)
    tris (3,5-dimethylphenyl-
    carbamate)
    tris (3,5-dichlorophenyl-
    carbamate)
    Type coated immobilised immobilised
    Phase Code KAN KCN KSA KSB KSC
    Particle Sizes [µm] 10, 20 10, 20 10, 20
    Pore Size widepore widepore widepore
    Separation Mode NP/SFC RP/NP/SFC RP/NP/SFC
    pH Range 3.5 - 6.5 2.0 - 9.0 2.0 - 9.0

     

      YMC CHIRAL Prep CD ST YMC CHIRAL Prep CD PM
    Chiral Selector β-Cylcodextrin Phenyl modified β-Cylcodextrin
    Phase Code ST PM
    Particle Sizes [µm] 10, 20, 50 10, 20, 50
    Pore Size [nm / Å] 12 / 120 12 / 120
    Seperation Mode RP RP/NP
    pH Range 2.0 - 7.0 2.0 - 7.0

     

    CHIRAL ART Amylose-C/Cellulose-C (coated)
    Phase Code KAN KCN
    Chiral Selector Amylose tris (3,5-dimethylphenylcarbamate) USP L51 Cellulose tris (3,5-dimethylphenylcarbamate) USP L40
    Type coated
    Particle Sizes 10, 20 µm
    Seperation Mode NP/SFC
    pH-range 3.5 - 6.5

    CHIRAL ART Amylose-C and Cellulose-C are based on a YMC silica packing material coated with the polysaccharide derivatives. They offer a wide application range with high durability, and are also suitable for SMB/SFC.

    Both 20 µm and 10 µm material is available in bulk size in multi kilogram quantities!

    CHIRAL ART Amylose-SA/Cellulose-SB/Cellulose-SC (immobilised)
    Phase Code KSA KSB KSC
    Chiral Selector Amylose tris (3,5-dimethylphenylcarbamate) Cellulose tris (3,5-dimethylphenylcarbamate) Cellulose tris (3,5-dichlorophenylcarbamate)
    Type immobilised
    Particle Sizes 10, 20 µm
    Seperation Mode RP/NP/SFC
    pH-range 2.0 - 9.0

     

    CHIRAL ART Amylose-SA and Cellulose-SB are based on a YMC silica packing material to which the polysaccharide derivatives is covalently bonded. They can be used either in normal phase or reversed phase modes.

    CHIRAL ART Amylose-SA and Cellulose-SB are very robust and are also suitable for SMB/SFC applications.
    The pricing of CHIRAL ART Amylose-SA and Cellulose-SB is very attractive.

    YMC CHIRAL Prep CD ST/PM
    Phase Code ST PM
    Chiral Selector β-Cylcodextrin Phenyl modified β-Cylcodextrin
    Pore Size 12 nm / 120 Å 12 nm / 120 Å
    Particle Sizes 10, 20, 50 µm 10, 20, 50 µm
    Seperation Mode RP RP/NP
    pH Range 2.0 - 7.0 2.0 - 7.0

     

    YMC Chiral Prep CD is a cyclic malto-oligosaccharide, consisting of seven α-D-glucopyranose units linked through α-(1,4)-linkages (β-cyclodextrin), covalently bonded to YMC's high-purity silica gel.

    YMC Chiral Prep CD is available in two versions with different selectivities: The unmodified standard (ST) version is suitable for reversed phase applications whilst the phenyl modified (PM) version can be used under both normal and reversed phase conditions.

    Title Document Type Language Phase Type Download
    Robust and Efficient Purification of Enantiomers with CHIRAL ART Cellulose-SB Application Note E
    YMC Chiral Columns Brochure E
    CHIRAL ART Amylose-C, Cellulose-C Prep Care and Use Care and Use Instructions E
    CHIRAL ART Amylose-SA, Cellulose-SB, Cellulose-SC Prep Care and Use Care and Use Instructions E
    YMC CHIRAL CD, NEA, Prep Care and Use Care and Use Instructions E
    Chapter Main Catalogue - YMC Chiral Columns Catalogue E
    MSDS Silica based NP/RP Bulk MSDS E
    Bulk Packing Material for Preparative Chromatography Overview E
    CHIRAL ART Cellulose-SC available in Prep Product Information E Please login

    Order Now

    Please contact YMC for pricing or specific solutions for your purification process.

    Michael Ostendorf

    Product Manager Bulk Media

    ph. +49 (0)2064 427-280

    Particle Size CHIRAL ART Amylose-C CHIRAL ART Amylose-SA CHIRAL ART Cellulose-C CHIRAL ART Cellulose-SB CHIRAL ART Cellulose-SC
    YMC CHIRAL Prep
    CD ST
    CD PM
    10 µm KAN99S11 KSA99S11 KCN99S11 KSB99S11 KSC99S11 ST12S11 PM12S11
    20 µm KAN99S21 KSA99S21 KCN99S21 KSB99S21 KSC99S21 ST12S21 PM12S21
    50 µm - - - -   ST12S50 PM12S50

     

    Related Categories

    Contact

    • Michael Ostendorf
    • Product Manager
    • Bulk Media
    • ph. +49 (0)2064 427-280