Synthesis and Analysis

Synthesis and Analysis

Synthesis and Analysis

    Synthesis and Analysis (SA) System

    The Synthesis and Analysis (SA) System has all the functionality of the 4 Channel Synthesis System but also enables each reaction to be automatically analysed by HPLC.

    The Synthesis and Analysis (SA) System is ideal for use in the following applications:

    • Medicinal chemistry
      • Method development (semi automated)
    • Process chemistry
      • Reaction optimisation (semi automated)

    Africa benefits:

    • Walk away synthesis: Fully automated hardware is controlled by the Africa software to enable unattended runs. Reagents are injected and products are collected automatically.
    • Faster reactions: Increase reaction rates over 100 fold by superheating reactions significantly above reflux e.g. dichloromethane to 100°C, acetonitrile to 150°C and water to 170°C.
    • Cleaner reactions: Reduced impurities via excellent, reproducible reaction control and optional use of solid phase reagents/catalysts/scavengers.
    • Inline aqueous work-up: The Flow Liquid Liquid Extraction Module (FLLEX) enables two immiscible phases to be mixed and separated in flow, immediately following the reaction.
    • Online analysis: A sample of reaction mixture can be taken, diluted and analyzed by HPLC in an entirely automated fashion.
    • Scale-up: Production rates up to kg overnight.
    • Automated LogP / LogD analysis: Excellent correlation with shake flask method.
    • Rapid development: Reaction time, temperature and equivalents can be rapidly varied using mg of substrate.
    • Reactions not possible with batch synthesis: Extremely quick reaction times, reagent additions, temperature changes and quenches are possible.
    • Automated blockage protection: Pressure sensors continually monitor every flow channel.
    • Wide temperature range: Heat reactions up to 250°C or cool down to 0°C.
    • Chemically resistant: Glass and PTFE/ fluoropolymer wetted part
    4 Syringe Pumps: Flow rate 2.5µl to 2.5ml/min with pressure sensors and automatic over-pressure shutdown
    4 Pressurized Input Bottles: Regulated 1 bar Nitrogen or Argon is supplied to up to 4 bottles, eliminating cavitation and bubble formation and allowing the use of air sensitive reagents (requires laboratory gas supply).
    4 Manual Injection Loops and Valves: 1ml, 5ml or 10ml loops
    Automatic Reagent Injection: The RIM allows reagents stored on the robot deck to be automatically aspirated and loaded into one of 4 injection loops. The robot has a coaxial needle allowing the use of air sensitive reagents in vials. All timings are automatically managed, even for complex, multi-reactor systems. Samples are pre-pressurized before injection into the flowing stream.
    Chemical Resistance: All wetted parts are glass, PTFE or other similar fluoropolymer.
    2 Temperature Controlled Microreactor Positions: The Africa Heater/Cooler has two reaction positions, each of which can be factory set to either:
    0°C – 150°C
    40°C – 250°C
    Reaction Sampling:

    The Sampler and dilutor takes a 5µl sample from the flowing stream, dilutes it by up to 250 fold and injects it onto an analytical system e.g. HPLC, LCMS, UPLC etc.
    HPLC Analysis: The Africa HPLC allows integrated synthesis conditions an HPLC traces.
    Automation: The Africa software allows an almost unlimited number of reactor configurations and automates the entire process. Only “chemist friendly” data such as volumes, times and temperatures need to be added – no need to deal with flow rates if you don’t want to. The timings of all events such as pumps starting, injections, collections etc. are all automatically calculated and performed automatically.


    System Details
    Africa 50ul Syringe for SAD
    Africa 2.5ml Syringe for SAD
    Africa Heater/Cooler (2 position)
    Africa 50/100ul Syringe Kit
    Africa 250/500ul Syringe Kit
    Africa 500/1000ul Syringe Kit
    Africa Reagent Pump
    62.5ul Microreactor Chip 2 Input
    62.5ul Microreactor Chip 3 Input
    250ul Microreactor Chip 2 Input
    250ul Microreactor Chip 3 Input
    1000ul Microreactor Chip 2 Input
    1000ul Microreactor Chip 3 Input
    Chip Header
    Africa Reagent Store (4 position Manual injection)
    Pressure Sensor Assembly for Africa Reagent Pump
    Africa Reagent Pump Valve Head
    Chip Header Blanking Plug
    Africa HPLC Pump
    Africa Sampler and Dilutor
    Africa Solvent Store
    Africa UV Detector
    Africa Heater/Cooler High Temp Sub Module
    4ml Tube Reactor PTFE
    16ml Tube Reactor PTFE
    4ml Tube Reactor PFA
    16ml Tube Reactor PFA
    Africa Pressurisation module
    Africa Control Software Including PC


      Name Type Format Language Download
    Africa Brochure Brochure PDF E Download


    Related Categories


    • Marc Ujma
    • Product Specialist Synthesis
    • ph. +49 (0)2064 427-281