4 Channel Synthesis

4 Channel Synthesis

4 Channel Synthesis

    4 Channel Synthesis (S) System

    The 4 Channel Synthesis System enables pressurised flow reactions with 4 independently controlled substrate/reagent inputs and two reaction locations, independently temperature controlled.

    The 4 Channel Synthesis System (S) is ideal for use in the following applications:

    • Medicinal chemistry
      • Flow chemistry investigations
      • Intermediate production
      • Synthetic conditions not possible in regular batch chemistry
    • Process chemistry
      • Reaction optimisation (manual collections)
      • Early scale-up
    • Degradation testing
    • Stability studies
    Specifications
    4 Syringe Pumps: Flow rate 2.5µl to 2.5ml/min with pressure sensors and automatic over-pressure shutdown
    4 Pressurized Input Bottles: Regulated 1 bar Nitrogen or Argon is supplied to up to 4 bottles, eliminating cavitation and bubble formation and allowing the use of air sensitive reagents (requires laboratory gas supply).
    Automatic Reagent Injection: The RIM allows reagents stored on the robot deck to be automatically aspirated and loaded into one of 4 injection loops. The robot has a coaxial needle allowing the use of air sensitive reagents in vials. All timings are automatically managed, even for complex, multi-reactor systems. Samples are pre-pressurized before injection into the flowing stream.
    Chemical Resistance: All wetted parts are glass, PTFE or other similar fluoropolymer.
    2 Temperature Controlled Microreactor Positions: The Africa Heater/Cooler has two reaction positions, each of which can be factory set to either:
    • 0°C – 150°C
    • 40°C – 250°C
    Automated Product Collection: Each different reaction is automatically collected in a different vial. The vial (or vessel) size is set by the user. Reactions larger than the vial size are automatically collected across multiple vials or preparative quantities can be collected in large one vessel.
    Automation: The Africa software allows an almost unlimited number of reactor configurations and automates the entire process. Only “chemist friendly” data such as volumes, times and temperatures need to be added – no need to deal with flow rates if you don’t want to. The timings of all events such as pumps starting, collections etc. are all automatically calculated.
    System Details
    Africa Heater/Cooler (2 position)
    Africa 50/100ul Syringe Kit
    Africa 250/500ul Syringe Kit
    Africa 500/1000ul Syringe Kit
    Africa Reagent Pump
    62.5ul Microreactor Chip 2 Input
    62.5ul Microreactor Chip 3 Input
    250ul Microreactor Chip 2 Input
    250ul Microreactor Chip 3 Input
    1000ul Microreactor Chip 2 Input
    1000ul Microreactor Chip 3 Input
    Chip Header
    Africa Reagent Store (4 position Manual injection)
    Pressure Sensor Assembly for Africa Reagent Pump
    Africa Reagent Pump Valve Head
    Chip Header Blanking Plug
    Africa Solvent Store
    Africa Heater/Cooler High Temp Sub Module
    4ml Tube Reactor PTFE
    16ml Tube Reactor PTFE
    4ml Tube Reactor PFA
    16ml Tube Reactor PFA
    Africa Pressurisation module
    Africa Control Software Including PC

    Downloads

      Name Type Format Language Download
    Africa Brochure Brochure PDF E Download
    Syrris Flow Chemistry Publications May 2013 Brochure PDF E Download

     

    Related Categories

    Contact

    • Marc Ujma
    • Product Specialist Synthesis
    • ph. +49 (0)2064 427-281