Full Africa System

Full Africa System

Full Africa System

    Full AFRICA System

    The full Africa Synthesis, Analysis, Liquid Handling and FLLEX (SAHF) System enables entirely automated flow synthesis, analysis, aqueous work up, reagent injection and product collection.

    The full Africa Synthesis, Analysis, Liquid Handling and FLLEX (SAHF) System is ideal for use in the following applications:

    • Medicinal Chemistry
      • Log D determination (fully automated)
      • Library production (fully automated)
    • Process Chemistry
      • Log P determination (fully automated)

    Africa benefits:

    • Walk away synthesis: Fully automated hardware is controlled by the Africa software to enable unattended runs. Reagents are injected and products are collected automatically.
    • Faster reactions: Increase reaction rates over 100 fold by superheating reactions significantly above reflux e.g. dichloromethane to 100°C, acetonitrile to 150°C and water to 170°C.
    • Cleaner reactions: Reduced impurities via excellent, reproducible reaction control and optional use of solid phase reagents/catalysts/scavengers.
    • Inline aqueous work-up: The Flow Liquid Liquid Extraction Module (FLLEX) enables two immiscible phases to be mixed and separated in flow, immediately following the reaction.
    • Online analysis: A sample of reaction mixture can be taken, diluted and analyzed by HPLC in an entirely automated fashion.
    • Scale-up: Production rates up to kg overnight.
    • Automated LogP / LogD analysis: Excellent correlation with shake flask method.
    • Rapid development: Reaction time, temperature and equivalents can be rapidly varied using mg of substrate.
    • Reactions not possible with batch synthesis: Extremely quick reaction times, reagent additions, temperature changes and quenches are possible.
    • Automated blockage protection: Pressure sensors continually monitor every flow channel.
    • Wide temperature range: Heat reactions up to 250°C or cool down to 0°C.
    • Chemically resistant: Glass and PTFE/ fluoropolymer wetted part
    Specifications
    2 Syringe Pumps: Flow rate 2.5µl to 2.5ml/min with pressure sensors and automatic over-pressure shutdown
    4 Pressurized Input Bottles: Regulated 1 bar Nitrogen or Argon is supplied to up to 4 bottles, eliminating cavitation and bubble formation and allowing the use of air sensitive reagents (requires laboratory gas supply).
    Automatic Reagent Injection: The RIM allows reagents stored on the robot deck to be automatically aspirated and loaded into one of 4 injection loops. The robot has a coaxial needle allowing the use of air sensitive reagents in vials. All timings are automatically managed, even for complex, multi-reactor systems. Samples are pre-pressurized before injection into the flowing stream.
    Chemical Resistance: All wetted parts are glass, PTFE or other similar fluoropolymer.
    2 Temperature Controlled Microreactor Positions: The Africa Heater/Cooler has two reaction positions, each of which can be factory set to either:
    0°C – 150°C
    40°C – 250°C
    Flow Liquid-Liquid Extraction: Flow extraction and separation of an extremely wide range of immiscible solvent pairs e.g. DCM:Aq, Ethyl Acetate:Aq, THF:Aq, Ether:Aq etc. (where Aq is aqueous).
    Reaction Sampling: The Sampler and dilutor takes a 5ul sample from the flowing stream, dilutes it by up to 250 fold and injects it onto an analytical system e.g. HPLC, LCMS, UPLC etc.
    HPLC Analysis: The Africa HPLC allows integrated synthesis conditions an HPLC traces.
    Automated Product Collection: Each different reaction is automatically collected in a different vial. The vial (or vessel) size is set by the user. Reactions larger than the vial size are automatically collected across multiple vials or preparative quantities can be collected in large one vessel.

     

    System Details
    Africa 50ul Syringe for SAD
    Africa 2.5ml Syringe for SAD
    Africa Heater/Cooler (2 position)
    Africa 50/100ul Syringe Kit
    Africa 250/500ul Syringe Kit
    Africa 500/1000ul Syringe Kit
    Africa Reagent Pump
    62.5ul Microreactor Chip 2 Input
    62.5ul Microreactor Chip 3 Input
    250ul Microreactor Chip 2 Input
    250ul Microreactor Chip 3 Input
    1000ul Microreactor Chip 2 Input
    1000ul Microreactor Chip 3 Input
    Chip Header
    10 ml Sample Loop
    1ml Sample Loop
    Pressure Sensor Assembly for Africa Reagent Pump
    Africa Reagent Pump Valve Head
    Chip Header Blanking Plug
    Africa HPLC Pump
    Africa Sampler and Dilutor
    Africa Solvent Store
    Africa UV Detector
    Africa Heater/Cooler High Temp Sub Module
    4ml Tube Reactor PTFE
    16ml Tube Reactor PTFE
    4ml Tube Reactor PFA
    16ml Tube Reactor PFA
    Africa FLLEX
    Africa PCM Basic
    Africa Pressurisation module
    Africa Control Software Including PC

    Downloads

      Name Type Format Language Download
    Africa Brochure Brochure PDF E Download
    Syrris Flow Chemistry Publications May 2013 Brochure PDF E Download

     

    Related Categories

    Contact

    • Marc Ujma
    • Product Specialist Synthesis
    • ph. +49 (0)2064 427-281